Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>CID 5951923

CID 5951923

CID 5951923 Structure
CID 5951923 structure
CAS No.
749872-43-3
Chemical Name:
CID 5951923
Synonyms
AC1NZ6UQ;CID 5951923;KLF5 Inhibitor, CID 5951923;KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem;[2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate;2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me;2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl (E)-3-(3-nitrophenyl)prop-2-enoate;3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester
CBNumber:
CB82574686
Molecular Formula:
C16H18N2O7S
Molecular Weight:
382.39
MDL Number:
MFCD04796932
MOL File:
749872-43-3.mol
MSDS File:
SDS
Last updated:2023-09-04 15:51:00
Request For Quotation

CID 5951923 Properties

Boiling point 646.9±55.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO: soluble10mg/mL (clear solution)
pka -1.40±0.20(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

CID 5951923 price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 422625 KLF5 Inhibitor, CID 5951923 749872-43-3 10mg $172 2024-03-01 Buy
Sigma-Aldrich SML0375 CID 5951923 ≥98% (HPLC) 749872-43-3 5mg $113 2022-05-15 Buy
Cayman Chemical 21649 CID 5951923 ≥98% 749872-43-3 1mg $32 2024-03-01 Buy
Cayman Chemical 21649 CID 5951923 ≥98% 749872-43-3 5mg $109 2024-03-01 Buy
Cayman Chemical 21649 CID 5951923 ≥98% 749872-43-3 10mg $139 2024-03-01 Buy
Product number Packaging Price Buy
422625 10mg $172 Buy
SML0375 5mg $113 Buy
21649 1mg $32 Buy
21649 5mg $109 Buy
21649 10mg $139 Buy

CID 5951923 Chemical Properties,Uses,Production

Uses

This compound acts as a KLF-5 expression inhibitor. which in turn reduces proliferation cell rates in colorectal cancer cells in humans.

General Description

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 μM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182.

CID 5951923 Preparation Products And Raw materials

Raw materials

Preparation Products

CID 5951923 Suppliers

Global( 57)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94838 76
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979 info@tsbiochem.com China 8073 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Pharmacodia (Beijing) Co.,Ltd +86-400-851-9921 sales@pharmacodia.com China 2317 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Amadis Chemical Company Limited 		58
J & K SCIENTIFIC LTD. 76
BOC Sciences 65
Shanghai TaoSu Biochemical Technology Co., Ltd. 58
Sigma-Aldrich 80
EMMX Biotechnology LLC 60
Pharmacodia (Beijing) Co.,Ltd 55

CID 5951923 Spectrum

CID 5951923(749872-43-3)1HNMR
CID 5951923 3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester [2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate AC1NZ6UQ 3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me KLF5 Inhibitor, CID 5951923 3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl (E)-3-(3-nitrophenyl)prop-2-enoate 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate Krüppel-like factor,CID-5951923,CID5951923,KLF5,inhibit,cancer,factor,KLF,transcription,Inhibitor,Krüppel-like,CID 5951923 2-Propenoic acid, 3-(3-nitrophenyl)-, 2-[methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl ester 749872-43-3 Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals