ARRY-520
- CAS No.
- 885060-09-3
- Chemical Name:
- ARRY-520
- Synonyms
- Filanesib;ARRY 520 trifluoroacetate;CS-512;ARRY-520;Filanesib(ARRY-520);Arry-520 (Filanesib);ARRY-520 Hydrochloride;FILANESIB;ARRY 520;ARRY520; (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide;(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide
- CBNumber:
- CB82582928
- Molecular Formula:
- C20H22F2N4O2S
- Molecular Weight:
- 420.48
- MDL Number:
- MOL File:
- 885060-09-3.mol
- MSDS File:
- SDS
| Boiling point | 511.3±60.0 °C(Predicted) |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 10.10±0.10(Predicted) |
| color | Off-white |
| FDA UNII | 8A49OSO368 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
ARRY-520 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21883 | ARRY-520 ≥98% | 885060-09-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21883 | ARRY-520 ≥98% | 885060-09-3 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 21883 | ARRY-520 ≥98% | 885060-09-3 | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 21883 | ARRY-520 ≥98% | 885060-09-3 | 25mg | $381 | 2024-03-01 | Buy |
| Tocris | 4676 | ARRY520trifluoroacetate ≥98%(HPLC) | 885060-09-3 | 10 | $254 | 2021-12-16 | Buy |
ARRY-520 Chemical Properties,Uses,Production
Uses
(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide is a known potent kinesin spindle protein inhibitor
Biological Activity
arry 520 trifluoroacetate is a synthetic and salt form of ksp inhibitor with ic50 value of 6 nm.kinesin spindle protein (ksp) is one member of the mitotic kinesins involved in the early stages of mitosis responsible for centrosome separation.
in vitro
arry-520 had low nanomolar antiproliferative activity in various tumor cell lines and exhibited activity in multidrug-resistant cell lines. ec50s of arry-520 for proliferation inhibition in hct-15, nci/adr-res and k562/adr cells was 3.7, 14 and 4.2 nm, respectively, while paclitaxel ec50s in these cell lines was 35, 565 and 372 nm. moreover, k562/adr was found to be 118-fold resistant to paclitaxel when compared to the parent k562 line, but only 3.5-fold resistant to that of arry-520 [1].
in vivo
arry-520 was found to be active in uiso-bca-1 xenografts, which were completely resistant to paclitaxel. the antitumor efficacy of arry-520 was also found to be superior to paclitaxel in mice bearing ht-29, hct-116, mda-mb-231 and a2780 xenografts. arry-520 was superior to docetaxel in the androgen receptor-negative prostate cancer pc-3 xenograft model, and was also superior to docetaxel in the du145 prostate xenograft model [1].
ARRY-520 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from ARRY-520 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-10-14 | Filanesib(ARRY-520)
885060-09-3
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2020-01-02 | (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
885060-09-3
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- Filanesib(ARRY-520)
885060-09-3
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
885060-09-3
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co