- Filanesib(ARRY-520)
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- $0.00 / 1KG
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2022-10-14
- CAS:885060-09-3
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
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| | ARRY-520 Basic information |
| Product Name: | ARRY-520 | | Synonyms: | (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide;1,3,4-Thiadiazole-3(2H)-carboxamide, 2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-, (2S)-;Arry-520 (Filanesib);ARRY-520;FILANESIB;ARRY 520;ARRY520;ARRY-520 Hydrochloride;Filanesib(ARRY-520);CS-512 | | CAS: | 885060-09-3 | | MF: | C20H22F2N4O2S | | MW: | 420.48 | | EINECS: | | | Product Categories: | | | Mol File: | 885060-09-3.mol |  |
| | ARRY-520 Chemical Properties |
| Boiling point | 511.3±60.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | solid | | pka | 10.10±0.10(Predicted) | | color | Off-white |
| | ARRY-520 Usage And Synthesis |
| Uses | (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide is a known potent kinesin spindle protein inhibitor | | Biological Activity | arry 520 trifluoroacetate is a synthetic and salt form of ksp inhibitor with ic50 value of 6 nm.kinesin spindle protein (ksp) is one member of the mitotic kinesins involved in the early stages of mitosis responsible for centrosome separation. | | in vitro | arry-520 had low nanomolar antiproliferative activity in various tumor cell lines and exhibited activity in multidrug-resistant cell lines. ec50s of arry-520 for proliferation inhibition in hct-15, nci/adr-res and k562/adr cells was 3.7, 14 and 4.2 nm, respectively, while paclitaxel ec50s in these cell lines was 35, 565 and 372 nm. moreover, k562/adr was found to be 118-fold resistant to paclitaxel when compared to the parent k562 line, but only 3.5-fold resistant to that of arry-520 [1]. | | in vivo | arry-520 was found to be active in uiso-bca-1 xenografts, which were completely resistant to paclitaxel. the antitumor efficacy of arry-520 was also found to be superior to paclitaxel in mice bearing ht-29, hct-116, mda-mb-231 and a2780 xenografts. arry-520 was superior to docetaxel in the androgen receptor-negative prostate cancer pc-3 xenograft model, and was also superior to docetaxel in the du145 prostate xenograft model [1]. |
| | ARRY-520 Preparation Products And Raw materials |
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