GeMigliptin
- CAS No.
- 911637-19-9
- Chemical Name:
- GeMigliptin
- Synonyms
- LC15-0444;GeMigliptin;GeMigliptin WS;Gemigliptin - G10587;GeMigliptin Tartarate;Gemigliptin Hydrochloride;Product name:-Gemigliptintartarate;Inhibitor,DPP,Gemigliptin,Dipeptidyl Peptidase,inhibit;(S)-1-(2-Amino-4-(2,4-bis(trifluoromethyl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one;1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one
- CBNumber:
- CB82627898
- Molecular Formula:
- C18H19F8N5O2
- Molecular Weight:
- 489.36
- MDL Number:
- MFCD19443742
- MOL File:
- 911637-19-9.mol
- MSDS File:
- SDS
| Boiling point | 539.1±50.0 °C(Predicted) |
|---|---|
| Density | 1.54±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:74.0(Max Conc. mg/mL);151.21(Max Conc. mM) Ethanol:7.0(Max Conc. mg/mL);14.3(Max Conc. mM) Water:12.0(Max Conc. mg/mL);24.52(Max Conc. mM) |
| pka | 7.33±0.10(Predicted) |
| FDA UNII | 5DHU18M5D6 |
| NCI Drug Dictionary | gemigliptin |
| ATC code | A10BH06 |
GeMigliptin price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | G337000 | GemigliptinHydrochloride | 911637-19-9 | 25mg | $13125 | 2021-12-16 | Buy |
| Matrix Scientific | 122479 | Gemigliptin 97.0% | 911637-19-9 | 1g | $2655 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013914 | GEMIGLIPTIN 95.00% | 911637-19-9 | 10MG | $1582.35 | 2021-12-16 | Buy |
| ChemScene | CS-0003618 | Gemigliptin | 911637-19-9 | 10mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-0003618 | Gemigliptin | 911637-19-9 | 50mg | $330 | 2021-12-16 | Buy |
GeMigliptin Chemical Properties,Uses,Production
Description
Gemigliptin is a prolyl-specific dipeptidyl aminopeptidase IV (DPP IV, DPP-4, CD26) inhibitor approved for the treatment of type 2 diabetes mellitus by the Korean Food and Drug Administration in 2012. Gemigliptin was discovered and developed by LG Life Sciences and is now the sixth DPP-4 inhibitor approved for the treatment of type 2 diabetes. At the time this review was prepared, there were no publications describing the discovery strategy and preclinical data that led to the advancement of gemigliptin to the clinic.
Uses
Gemigliptin Hydrochloride is used in biological studies as a novel dipeptidyl peptidase IV (DPP-IV) inhibitors and potential antidiabetic drug.
Definition
ChEBI: Gemigliptin is an organonitrogen compound and an organooxygen compound. It is functionally related to a beta-amino acid.
Synthesis
Commercial N-Boc-3-piperidone (71) was treated
with LHMDS followed by ethyl trifluoroacetate to effect a Claisen
condensation, producing diketone 72 in 81% yield. Cyclization of
72 with 2,2,2-trifluoroacetamide (73) gave bis-trifluoromethyl
dihydropyridopyrimidine 74 in 23% yield. Removal of the Boc protecting
group efficiently provided amine 75 in 96% yield.
1,4-Addition of ethyl bromodifluoroacetate
(76) to ethyl acrylate (77) in the presence of
copper powder and tetramethylethylenediamine (TMEDA) gave
diester 78, which was selectively reduced with sodium borohydride
(NaBH4) to give alcohol 79 in 90% overall yield for the
two-step procedure. Alcohol 79 was then treated with perfluorobutanesulfonyl
chloride and triethylamine to give activated
alcohol 80 in 75% yield.
Boc-L-aspartic acid 4-tert-butyl ester (81) was treated
with ammonium bicarbonate and pyridine in the presence of
di-tert-butyl dicarbonate to give formamide 82. Dehydration of
82 to give nitrile 83 was accomplished through reaction with cyanuric
chloride in 95% overall yield for the two-step sequence.
Hydrogenation of 83 in the presence of Pearlman?ˉs catalyst provided butyl amine 84. Alkylation of 84 with activated alcohol
80 in triethylamine followed by cyclization in acetic acid afforded
difluoropyridone 85. Acidic hydrolysis of the ester proceeded with
concomitant removal of the Boc protecting group, and was followed
by reprotection of the amine with di-tert-butyl dicarbonate
to give acid 86 in 84% overall yield for the three-step procedure in
>97% ee. Coupling of 86 with fragment 75 in the presence of 1-hydroxybenzotriazole
(HOBT) and 1-ethyl-3-(3-dimethylaminopropyl)
carbodiimide (EDC) gave amide 87 in 51% yield. Removal
of the Boc group with thionyl chloride in ethanol followed by neutralization
with aqueous sodium hydroxide and salt formation
with L-tartaric acid provided gemigliptin L-tartrate hydrate (X) in
97.5% yield.
GeMigliptin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
| Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 | info@senovatech.com | China | 350 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
View Lastest Price from GeMigliptin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-01 | Gemigliptin Tartarate
911637-19-9
|
US $0.00-0.00 / g | 1g | 98% | 250 | Senova Technology Co. Ltd. |
-
- Gemigliptin Tartarate
911637-19-9
- US $0.00-0.00 / g
- 98%
- Senova Technology Co. Ltd.