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LP533401 hcl

LP533401 hcl Structure
LP533401 hcl structure
CAS No.
1040526-12-2
Chemical Name:
LP533401 hcl
Synonyms
CS-1770;LP533401 hcl;LP-533401 hydrochloride;LP 533401 hydrochloride,LP533401 hydrochloride;(2S)-2-Amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid hydrochloride;L-?Phenylalanine, 4-?[2-?amino-?6-?[2,?2,?2-?trifluoro-?1-?(3'-?fluoro[1,?1'-?biphenyl]?-?4-?yl)?ethoxy]?-?4-?pyrimidinyl]?-?, hydrochloride (1:1);L-phenylalanine, 4-[2-amino-6-[2,2,2-trifluoro-1-(3'-fluoro[1,1'-biphenyl]-4-yl)ethoxy]-4-pyrimidinyl]-, Hydrochloride (1:1) LP533401 hcl
CBNumber:
CB82731287
Molecular Formula:
C27H23ClF4N4O3
Molecular Weight:
562.95
MDL Number:
MFCD18803629
MOL File:
1040526-12-2.mol
Last updated:2023-05-18 11:31:12
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LP533401 hcl Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility ≥56.3 mg/mL in DMSO; insoluble in H2O; ≥19.4 mg/mL in EtOH
form solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

LP533401 hcl price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0028599 LP-533401hydrochloride 98.09% 1040526-12-2 10mg $150 2021-12-16 Buy
ChemScene CS-0028599 LP-533401hydrochloride 98.09% 1040526-12-2 25mg $280 2021-12-16 Buy
ApexBio Technology B5823 LP533401hcl 1040526-12-2 25mg $280 2021-12-16 Buy
ChemScene CS-0028599 LP-533401hydrochloride 98.09% 1040526-12-2 50mg $450 2021-12-16 Buy
ChemScene CS-0028599 LP-533401hydrochloride 98.09% 1040526-12-2 100mg $610 2021-12-16 Buy
Product number Packaging Price Buy
CS-0028599 10mg $150 Buy
CS-0028599 25mg $280 Buy
B5823 25mg $280 Buy
CS-0028599 50mg $450 Buy
CS-0028599 100mg $610 Buy

LP533401 hcl Chemical Properties,Uses,Production

Biological Activity

lp533401 hcl is an inhibitor of tph-1 [1].tryptophan hydroxylase-1 (tph-1) is an isoenzyme of tryptophan hydroxylase and the initial enzyme in gut- and lung-derived serotonin biosynthesis. tph-1 is mainly expressed in the gut and lung [2].lp533401 hcl is a tph-1 inhibitor. in rat rbl2h3 cells expressing tph1, lp533401 (1 μm) completely inhibited serotonin production. lp533401 reduced the activity of recombinant wild-type tph-1 by 70% by interacting with residues tyr235 and phe241 [1].in rodents, lp533401 orally administration was incapable of crossing the blood-brain barrier. in mice, lp533401 (250 mg/kg) dose-dependently reduced serum serotonin concentration by 30%. in ovariectomized female c57bl6/j mice, lp533401 (10, 100, 250 mg/kg for 28 days) increased bone mass and bone-formation parameters such as osteocalcin serum concentration, osteoblast numbers and bone formation rate. also, lp533401 dose-dependently decreased serum serotonin concentration but didn’t affect brain serotonin content. in ovariectomized female rats, lp533401 completely rescued the ovariectomy-induced osteopenia [1]. in transgenic sm22-5-htt+ mice overexpressing 5-ht transporter (5-htt) in smooth muscle cells and spontaneously developing pulmonary hypertension (ph), lp533401 (250 mg/kg for 21 days) significantly reduced lung and blood 5-ht levels, vascular ki67-positive cells, distal pulmonary artery muscularization, right ventricular (rv) hypertrophy and rv systolic pressure [2].

References

[1]. yadav vk, balaji s, suresh ps, et al. pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis. nat med, 2010, 16(3): 308-312.
[2]. abid s, houssaini a, chevarin c, et al. inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. am j physiol lung cell mol physiol, 2012, 303(6): l500-508.

LP533401 hcl Preparation Products And Raw materials

Raw materials

Preparation Products

LP533401 hcl Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6730 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4153 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8012 62
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2985 58
Medi-tech Bioscientific Co., Ltd. 0519-83246372 13585352506 China 1844 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Amadis Chemical Company Limited 		58
Shanghai Balmxy Pharmaceutical Co., Ltd 55
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Shanghai Rechem science Co., Ltd. 58
Medi-tech Bioscientific Co., Ltd. 58

LP533401 hcl Spectrum

LP533401 hcl(1040526-12-2)1HNMR
L-phenylalanine, 4-[2-amino-6-[2,2,2-trifluoro-1-(3'-fluoro[1,1'-biphenyl]-4-yl)ethoxy]-4-pyrimidinyl]-, Hydrochloride (1:1) LP533401 hcl LP533401 hcl LP-533401 hydrochloride CS-1770 L-?Phenylalanine, 4-?[2-?amino-?6-?[2,?2,?2-?trifluoro-?1-?(3'-?fluoro[1,?1'-?biphenyl]?-?4-?yl)?ethoxy]?-?4-?pyrimidinyl]?-?, hydrochloride (1:1) LP 533401 hydrochloride,LP533401 hydrochloride (2S)-2-Amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3'-fluoro-[1,1'-biphenyl]-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid hydrochloride 1040526-12-2 C27H23ClF4N4O3