3-(Trifluoromethyl)cinnamic acid
- CAS No.
- 779-89-5
- Chemical Name:
- 3-(Trifluoromethyl)cinnamic acid
- Synonyms
- 3-[3-(TRIFLUOROMETHYL)PHENYL]PROP-2-ENOIC ACID;MTF-CNA;Cinacalcet-27;TIMTEC-BB SBB000553;RARECHEM BK HW 0018;CINMIC ACID IMPURITY;Cinacalcet Impurity 40;3-[3-(Trifluoromethyl)Pheny;m-(Trifluoromethyl)Cinnamic;3-rifluoromethyl)CinnamicAcid
- CBNumber:
- CB8295905
- Molecular Formula:
- C10H7F3O2
- Molecular Weight:
- 216.16
- MDL Number:
- MFCD00004393
- MOL File:
- 779-89-5.mol
Melting point | 135-137 °C(lit.) |
---|---|
Boiling point | 224°C (rough estimate) |
Density | 1.3275 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 4.25±0.10(Predicted) |
form | Solid |
color | White to Off-White |
BRN | 1963372 |
CAS DataBase Reference | 779-89-5(CAS DataBase Reference) |
FDA UNII | P9LJ9ON37W |
EPA Substance Registry System | 3-[3-(Trifluoromethyl)phenyl]acrylic acid (779-89-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38-37/38 | |||||||||
Safety Statements | 26-37/39-37 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | Yes | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29163990 | |||||||||
NFPA 704 |
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3-(Trifluoromethyl)cinnamic acid price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | T1547 | 3-(Trifluoromethyl)cinnamic Acid >99.0%(GC)(T) | 779-89-5 | 5g | $113 | 2024-03-01 | Buy |
TCI Chemical | T1547 | 3-(Trifluoromethyl)cinnamic Acid >99.0%(GC)(T) | 779-89-5 | 25g | $340 | 2024-03-01 | Buy |
Alfa Aesar | A16983 | 3-(Trifluoromethyl)cinnamic acid, predominantly trans, 98+% | 779-89-5 | 5g | $38.65 | 2024-03-01 | Buy |
Alfa Aesar | A16983 | 3-(Trifluoromethyl)cinnamic acid, predominantly trans, 98+% | 779-89-5 | 25g | $135.65 | 2024-03-01 | Buy |
TRC | T791225 | 3-(Trifluoromethyl)cinnamic Acid | 779-89-5 | 1g | $45 | 2021-12-16 | Buy |
3-(Trifluoromethyl)cinnamic acid Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
3-(Trifluoromethyl)cinnamic acid is used in the synthesis of cinacalcet. Cinacalcet is a drug for the control and treatment of secondary hyperparathyroidism (in the dialysis population), primary hyperparathyroidism where the patient may not be a candidate for surgical treatment, and for the treatment of calciphylaxis in patients with end-stage renal disease or in patients on dialysis.
Uses
Had sedative hypnotic activity in mice, showing potent inhibition of spontaneous motility.
Definition
ChEBI: (E)-3-(trifluoromethyl)cinnamic acid is a member of the class of (trifluoromethyl)benzenes consisting of trans-cinnamic acid having a trifluoromethyl substituent at the meta-position. It is a member of cinnamic acids, a member of styrenes and a member of (trifluoromethyl)benzenes. It is functionally related to a trans-cinnamic acid.
Synthesis
To a suspension of m-trifluoromethyl-α-bromohydrocinnamic acid, isopropanol (1.42 1) and benzyltriethylammonium chloride (10.85g), aqueous sodium hydroxide (340 ml, 56%) was added slowly. The temperature was raised to 55-60℃, stirred for 7 hours, and isopropanol was removed in vacuo. Water (500ml) was added to the reaction mass, stirred, cooled to 0℃, and acidified with hydrochloric acid (450ml). The solid was filtered, washed with water, and dried in vacuo at 5O℃ to afford 204g of 3-(Trifluoromethyl)cinnamic acid.
3-(Trifluoromethyl)cinnamic acid Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 | jennysun@yzqyyykj.com | China | 71 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5882 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 | angelia@hbmojin.com | China | 1069 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 | admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
View Lastest Price from 3-(Trifluoromethyl)cinnamic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | 3-(Trifluoromethyl)cinnamic acid
779-89-5
|
US $999.00-666.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | ||
2024-09-19 | 3- (Trifluoromethyl) Cinnamic Acid
779-89-5
|
US $10.00 / KG | 1KG | 99.8% | 100tons | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-08-15 | 3-(Trifluoromethyl)cinnamic acid
779-89-5
|
US $25.00-9.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
- 3-(Trifluoromethyl)cinnamic acid
779-89-5
- US $999.00-666.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- 3- (Trifluoromethyl) Cinnamic Acid
779-89-5
- US $10.00 / KG
- 99.8%
- Hebei Chuanghai Biotechnology Co,.LTD
- 3-(Trifluoromethyl)cinnamic acid
779-89-5
- US $25.00-9.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
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