Labetalol hydrochloride
- CAS No.
- 32780-64-6
- Chemical Name:
- Labetalol hydrochloride
- Synonyms
- LABETALOL HCL;normodyne;5-[1-HYDROXY-2-[(1-METHYL-3-PHENYLPROPYL)-AMINO]ETHYL]SALICYLAMIDE HYDROCHLORIDE;ipolab;labelol;ah5158a;amipress;Trandate;labrocol;presdate
- CBNumber:
- CB8334888
- Molecular Formula:
- C19H25ClN2O3
- Molecular Weight:
- 364.87
- MDL Number:
- MFCD00057663
- MOL File:
- 32780-64-6.mol
| Melting point | 187-189° |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | powder |
| color | white |
| FDA UNII | 1GEV3BAW9J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | CV5376000 |
| HS Code | 2924296000 |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 114, 120, 113, 107 i.p.; 47, 54, 60, 53 i.v.; 1450, 1800, 4550, 4000 orally (Shimpo) |
Labetalol hydrochloride price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L1011 | Labetalol hydrochloride >98% (TLC), powder | 32780-64-6 | 5g | $109 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1356654 | Labetalol hydrochloride United States Pharmacopeia (USP) Reference Standard | 32780-64-6 | 200mg | $436 | 2024-03-01 | Buy |
| Cayman Chemical | 20249 | Labetalol (hydrochloride) ≥98% | 32780-64-6 | 1g | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20249 | Labetalol (hydrochloride) ≥98% | 32780-64-6 | 5g | $93 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR1335 | Labetalol Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 32780-64-6 | 1g | $97.5 | 2024-03-01 | Buy |
Labetalol hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White or almost white powder.
Originator
Trandate,Allen and Hanburys,UK,1977
Uses
vasoconstrictor
Uses
tropane alkaloid, anticholinergic drug
Definition
ChEBI: Labetalol hydrochloride is a member of salicylamides.
Manufacturing Process
(a) 5-Bromoacetylsalicylamide (2.6 g), N-benzyl-N-(1-methyl-3-phenylpropyl)
amine (4.8 g) and methyl ethyl ketone (50 ml) were heated at reflux for 40
minutes. The solvent was removed and the residue was treated with benzene.
The secondary amine hydrobromide was filtered off and discarded, and the
filtrate was evaporated to dryness. The residue was treated with an excess of
ethanolic hydrogen chloride when 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)-
glycyl]-salicylamide hydrochloride (1.15 g) crystallized out, MP 139°C to
141°C.
(b) 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)glycyl]-salicylamide
hydrochloride (0.75 g), 10% mixture of PdO and PtO on carbon catalyst (0.1
g) and ethanol (20 ml) were shaken at room temperature and pressure with
hydrogen until uptake ceased. The catalyst was filtered off and the filtrate
evaporated to dryness. The residue was crystallized from ethanol to give 5-[1-
hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl]salicylamide hydrochloride as
a white solid (0.40 g), MP 188°C.
brand name
Normodyne (Schering); Trandate (Promethus).
Therapeutic Function
Alpha-adrenergic blocker, Beta-adrenergic blocker
Biological Activity
labetalol hcl is a selective antagonist for the α1-adrenergic receptor and a non-selective antagonist for the β-adrenergic receptor. labetalol hcl has been used for the treatment of high blood pressure. labetalol hcl competitively targets the α1-adrenergic receptors expressed in vascular smooth muscle, thus inhibiting adrenergic stimulation on endothelial cells and vasoconstriction in peripheral blood vessels. labetalol hcl also blocks the β-adrenergic receptors in bronchial and vascular smooth muscle to counteract adrenergic stimulation. ultimately, labetalol hcl causes decreases in resting and exercise heart rates, cardiac output, as well as in both systolic and diastolic blood pressure, exherting vasodilation, as well as negative chronotropic and inotropic cardiac effects.1. national center for biotechnology information (2021). pubchem compound summary for cid 3869, labetalol. retrieved august 21, 2021.2. dage rc, hsieh cp. direct vasodilatation by labetalol in anaesthetized dogs. british journal of pharmacology, 1980, 70(2): 287-293.
Labetalol hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9347 | 55 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 968 | 58 | |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9231 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
View Lastest Price from Labetalol hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-07-04 | Labetalol hydrochloride
32780-64-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2021-09-29 | Labetalol hydrochloride
32780-64-6
|
US $0.00 / Kg/Drum | 1KG | 98.5%-101.0% | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2021-08-11 | Labetalol hydrochloride USP/EP/BP
32780-64-6
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- Labetalol hydrochloride
32780-64-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Labetalol hydrochloride
32780-64-6
- US $0.00 / Kg/Drum
- 98.5%-101.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Labetalol hydrochloride USP/EP/BP
32780-64-6
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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