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WIN 55,212-2 MESYLATE

WIN 55,212-2 MESYLATE Structure
WIN 55,212-2 MESYLATE structure
CAS No.
131543-23-2
Chemical Name:
WIN 55,212-2 MESYLATE
Synonyms
WIN55;CS-754;WIN 55,212-2;212-2Mesylate;WIN552122;WIN-552122;WIN 55,212-2 MESYLATE;R(+)-WIN 55,212-2 MESYLATE;WIN 55212-2 methanesulfonate;(R)-(+)-WIN 55,212-2 mesylate salt;WIN552122;WIN-552122;(R)-(+)-WIN 55212
CBNumber:
CB8335502
Molecular Formula:
C28H30N2O6S
Molecular Weight:
522.62
MDL Number:
MFCD00153882
MOL File:
131543-23-2.mol
MSDS File:
SDS
Last updated:2024-03-22 14:56:24
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WIN 55,212-2 MESYLATE Properties

storage temp. Store at +4°C
solubility 0.1 M HCl: 0.25 mg/mL
form solid
color white to off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey FSGCSTPOPBJYSX-OZYVVJTJNA-N
SMILES S(O)(=O)(=O)C.C(N1CCOCC1)[C@@H]1COC2=CC=CC3C(C(C4=CC=CC5=CC=CC=C45)=O)=C(C)N1C=32 |&1:12,r|
FDA UNII 2J851TP7VJ

SAFETY

Risk and Safety Statements

WGK Germany  3

WIN 55,212-2 MESYLATE price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W102 (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC) 131543-23-2 25mg $446 2024-03-01 Buy
Sigma-Aldrich W102 (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC) 131543-23-2 100mg $910 2024-03-01 Buy
Cayman Chemical 10009023 (+)-WIN 55,212-2 (mesylate) ≥98% 131543-23-2 5mg $46 2024-03-01 Buy
Cayman Chemical 10009023 (+)-WIN 55,212-2 (mesylate) ≥98% 131543-23-2 10mg $88 2024-03-01 Buy
Cayman Chemical 10009023 (+)-WIN 55,212-2 (mesylate) ≥98% 131543-23-2 25mg $195 2024-03-01 Buy
Product number Packaging Price Buy
W102 25mg $446 Buy
W102 100mg $910 Buy
10009023 5mg $46 Buy
10009023 10mg $88 Buy
10009023 25mg $195 Buy

WIN 55,212-2 MESYLATE Chemical Properties,Uses,Production

Description

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C at a concentration of 1 μM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 μM.

Uses

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/? mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

General Description

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

Biological Activity

Nanomolar affinity cannabinoid receptor agonist (K i values are 62.3 and 3.3 nM at the human cloned CB 1 and CB 2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ .

Biochem/physiol Actions

It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.

storage

Store at +4°C

References

1) Felder?et al. (1995),?Comparison of the pharmacology and signal transduction of the human cannabinoid CB1?and CB2receptors; Mol. Pharmacol.,?48?443 2) Herzberg?et al. (1997),?The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist in a rat model of neuropathic pain; Neurosci. Lett.,?221?157 3) Bouaboula?et al. (1995),?Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1; Biochem. J.,?312?637

WIN 55,212-2 MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

WIN 55,212-2 MESYLATE Suppliers

Global( 150)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Kangcang new material Technology Co., LTD
+8615713292910 Nancy@kangcang.com.cn China 340 58
Hubei XinRunde Chemical Co., Ltd. 		+8615102730682 bruce@xrdchem.cn CHINA 566 55
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
TopScience Biochemical 		00852-68527855 info@itopbiochem.com China Hong Kong 902 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 6710 58
Supplier Advantage
Hebei Kangcang new material Technology Co., LTD
58
Hubei XinRunde Chemical Co., Ltd. 		55
Biochempartner 		58
Alchem Pharmtech,Inc. 		58
TopScience Biochemical 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Hebei Yanxi Chemical Co., Ltd. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Shanghai UCHEM Inc. 		58

View Lastest Price from WIN 55,212-2 MESYLATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WIN 55212-2 mesylate pictures 2024-04-30 WIN 55212-2 mesylate
131543-23-2
 US $20.00-10.00 / kg 1kg 98% 20 Hebei Kangcang new material Technology Co., LTD
WIN 55212-2 mesylate pictures 2024-04-30 WIN 55212-2 mesylate
131543-23-2
 US $9.00-60.00 / g 10g min99% 10 tons Hebei Kangcang new material Technology Co., LTD
(+)-Win 55212-2 mesylate pictures 2023-10-09 (+)-Win 55212-2 mesylate
131543-23-2
 US $0.00 / G 10G 0.99 1000g Hebei Yanxi Chemical Co., Ltd.
  • WIN 55212-2 mesylate pictures
  • WIN 55212-2 mesylate
    131543-23-2
  • US $20.00-10.00 / kg
  • 98%
  • Hebei Kangcang new material Technology Co., LTD
  • WIN 55212-2 mesylate pictures
  • WIN 55212-2 mesylate
    131543-23-2
  • US $9.00-60.00 / g
  • min99%
  • Hebei Kangcang new material Technology Co., LTD

131543-23-2(WIN 55,212-2 MESYLATE)Related Search:

SB216763 WIN 54461 7-Methoxy-3-indolecarboxaldehyde 7-Methoxy-1H-indole 2-Methylindole-3-carboxaldehyde
1-Ethyl-2-methylindole 7-Hydroxyindole 3-Acetylindole 3-Morpholinopropanol 1,2-Dimethylindole
1,2-DIMETHYL-1H-INDOLE-3-CARBOXALDEHYDE 1-Methylindole-3-carboxaldehyde [1-[2-(4-Morpholinyl)ethyl]-1H-indol-3-yl]-1-naphthalenylmethanone 1-(1-ETHYL-1H-INDOL-3-YL)ETHANONE 2-(1H-PYRROL-1-YL)-1-ETHANAMINE
ASISCHEM W99822 2-(1H-INDOL-1-YL)ETHANAMINE 2-(2-METHYL-1H-INDOL-1-YL)ETHANAMINE

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R(+)-WIN 55,212-2 ,MESYLATE HIGH AFFINIT Y CANNABI (R)-(+)-(2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1.2.3-de]-1,4-benzoxazin-6-yl)-1-naphthalenylmethanonemesy 212-2Mesylate WIN55 (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt (R)-(+)-WIN 55,212-2 mesylate salt WIN 552122 mesylate, (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone Methanesulfonate (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1-yl WIN 55212-2 methanesulfonate (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1 (R)-(+)-[2,3-DIHYDRO-5-METHYL-3-(4-MORPHOLINYLMETHYL)PYRROLO[1,2,3-DE]-1,4-BENZOXAZIN-6-YL]-1-NAPHTHALENYLMETHANONE MESYLATE R(+)-[2,3-DIHYDRO-5-METHYL-3-[(MORPHOLINYL)METHYL]PYRROLO[1,2,3-DE]-1,4-BENZOXAZINYL]-(1-NAPHTHALENYL)METHANONE MESYLATE R(+)-WIN 55,212-2 MESYLATE WIN 55,212-2 MESYLATE WIN 55,212-2 (+)-WIN 55,212-2 mesylate - CAS 131543-23-2 - Calbiochem CS-754 WIN552122;WIN-552122 WIN552122;WIN-552122;(R)-(+)-WIN 55212 [(3R)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone Monomethanesulfonate (R)-(+)-WIN 55,212-2 mesylate salt >=98% (HPLC) (R)-(+)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo1,2,3-de-1,4-benzoxazin-6-yl-1-naphthalenylmethan one mesylate 131543-23-2 C28H30N2O6S Cannabinoid receptor Cannabinoid