(S)-3,5-DIHYDROXYPHENYLGLYCINE
- CAS No.
- 162870-29-3
- Chemical Name:
- (S)-3,5-DIHYDROXYPHENYLGLYCINE
- Synonyms
- S-DHPG;(S)-3,5-DHPG;(S) 3,5 DHPG,(S)3,5DHPG;(S)-3,5-DIHYDROXYPHENYLGLYCINE;(S)-3,5-Dihydroxylphenylglycine;(S)-3,5-Dihydroxyphenylglycine hydrate;+-2,5-DIMETHOXY-4-IODOAMPHETAMINE HYDROCHLORIDE;(2S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid;Benzeneacetic acid, α-amino-3,5-dihydroxy-, (αS)-
- CBNumber:
- CB8453891
- Molecular Formula:
- C8H9NO4
- Molecular Weight:
- 183.16
- MDL Number:
- MFCD00673763
- MOL File:
- 162870-29-3.mol
- MSDS File:
- SDS
| Melting point | >207°C (dec.) |
|---|---|
| Boiling point | 448.8±33.0 °C(Predicted) |
| Density | 1.550±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Aqueous Base (Very Slightly, Sonicated), Methanol (Slightly), Water (Slightly, Heated) |
| pka | 1.77±0.10(Predicted) |
| form | solid |
| color | white |
| Water Solubility | Soluble to 50 mM in water |
| Stability | Hygroscopic |
| FDA UNII | CF5G2G268A |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
(S)-3,5-DIHYDROXYPHENYLGLYCINE price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D3689 | (S)-3,5-Dihydroxyphenylglycine hydrate ≥98% (HPLC), powder | 162870-29-3 | 5mg | $260 | 2024-03-01 | Buy |
| Sigma-Aldrich | D3689 | (S)-3,5-Dihydroxyphenylglycine hydrate ≥98% (HPLC), powder | 162870-29-3 | 10mg | $494 | 2024-03-01 | Buy |
| Cayman Chemical | 14411 | (S)-3,5-DHPG ≥98% | 162870-29-3 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 14411 | (S)-3,5-DHPG ≥98% | 162870-29-3 | 5mg | $126 | 2024-03-01 | Buy |
| Cayman Chemical | 14411 | (S)-3,5-DHPG ≥98% | 162870-29-3 | 10mg | $220 | 2024-03-01 | Buy |
(S)-3,5-DIHYDROXYPHENYLGLYCINE Chemical Properties,Uses,Production
Uses
(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal injury and cognitive enhancement.
Uses
(S)-3,5-Dihydroxyphenylglycine hydrate has been used:
- as mGluR1/5?agonist for metabotropic glutamate receptor 1 (mGluR1/5) activation in synaptoneurosomal preparations
- in ACSF for DHPG stimulation
- to inject into basolateral amygdala to study its effect on memory expression
Uses
(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal inju ry and cognitive enhancement.
Definition
ChEBI: (S)-3,5-dihydroxyphenylglycine is a glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups. It is a member of resorcinols and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-alpha-phenylglycine. It is a tautomer of a (S)-3,5-dihydroxyphenylglycine zwitterion.
Biological Activity
Selective group I mGlu receptor agonist. Also available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
Biochem/physiol Actions
(S)-3,5-Dihydroxyphenylglycine hydrate is a group I metabotropic glutamate receptor agonist.
storage
-20°C (desiccate). Protect from light.
(S)-3,5-DIHYDROXYPHENYLGLYCINE Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-3,5-DIHYDROXYPHENYLGLYCINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7019 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Supplier | Advantage |
|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Career Henan Chemica Co | 58 |
| Aladdin Scientific | 58 |
| J & K SCIENTIFIC LTD. | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 69 |
| Ascent Scientific | 60 |
| BOC Sciences | 65 |
| Sigma-Aldrich | 80 |
| EMMX Biotechnology LLC | 60 |