N-NITROSO-N-ETHYLUREA
- CAS No.
- 759-73-9
- Chemical Name:
- N-NITROSO-N-ETHYLUREA
- Synonyms
- ENU;NGL;anh;NEU;TKR1;Aenh;nsc45403;Kiaa3023;NSC 45403;ETHYLNITROSUREA
- CBNumber:
- CB8733913
- Molecular Formula:
- C3H7N3O2
- Molecular Weight:
- 117.11
- MDL Number:
- MFCD00053635
- MOL File:
- 759-73-9.mol
- MSDS File:
- SDS
| Melting point | 103-1040C (dec) |
|---|---|
| Boiling point | 182℃ |
| Density | 1.35 |
| refractive index | 1.4900 (estimate) |
| Flash point | 64℃ |
| storage temp. | -20°C |
| solubility | DMSO (Soluble), Methanol (Sparingly) |
| form | Semi-Solid to Low-Melting Solid |
| pka | 12.32±0.50(Predicted) |
| color | Off-White to Red |
| Water Solubility | 12.83g/L(room temperature) |
| Stability | Unstable at RT, Contains approximately 40% Water, 2.0% Acetic Acid to stabilize |
| CAS DataBase Reference | 759-73-9(CAS DataBase Reference) |
| EWG's Food Scores | 2 |
| FDA UNII | P8M1T4190R |
| IARC | 2A (Vol. 17, Sup 7) 1987 |
| Proposition 65 List | N-Nitroso-N-ethylurea |
| EPA Substance Registry System | N-Nitroso-N-ethylurea (759-73-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H312+H332-H350-H360 |
| Precautionary statements | P201-P202-P280-P301+P310-P302+P352+P312-P304+P340+P312 |
| Hazard Codes | T |
| Risk Statements | 45-46-61-20/21/22 |
| Safety Statements | 53-22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | YT3150000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 i.v. in rats: 240 mg/kg (Druckrey) |
N-NITROSO-N-ETHYLUREA price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N8509 | N-Nitroso-N-ethylurea Bulk package | 759-73-9 | 5g | $133 | 2024-03-01 | Buy |
| Sigma-Aldrich | N3385 | N-Nitroso-N-ethylurea ISOPAC | 759-73-9 | 1g | $60.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | N8509 | N-Nitroso-N-ethylurea Bulk package | 759-73-9 | 25g | $407 | 2024-03-01 | Buy |
| TRC | N526100 | N-Nitroso-N-ethylUrea,Contains40%water,1.8%AcOH | 759-73-9 | 100g | $1130 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0014755 | N-NITROSO-N-ETHYLUREA 95.00% | 759-73-9 | 10G | $1166.55 | 2021-12-16 | Buy |
N-NITROSO-N-ETHYLUREA Chemical Properties,Uses,Production
Chemical Properties
N-Nitroso-N-ethyl urea is a pale yellow, crystalline powder; freezing/melting point=103－104°C (decomposes). Hazard identification (based on NFPA-704 M Rating System): Health 2; flammability 1; reactivity 0?. Soluble in water; hydrolysis produces explosive gas.
Chemical Properties
Orange Paste
Uses
N-Nitroso-N-ethylurea has been used as a mutation-inducing agent.
Uses
A precursor of Diazoethane
Uses
Experimentally as mutagen; ethylating agent.
Definition
ChEBI: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.
General Description
Yellow-pink crystals or off-white powder. Sensitive to light.
Air & Water Reactions
Water soluble. Sensitive to moisture--stability in aqueous solutions depends on pH.
Reactivity Profile
N-NITROSO-N-ETHYLUREA is highly reactive. Sensitive to moisture and light. Its stability in aqueous solutions is pH-dependent. Incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly explosive gas. .
Hazard
Tumorigen, carcinogen, neoplastigen; teratogen; poison; toxic.
Health Hazard
ACUTE/CHRONIC HAZARDS: N-NITROSO-N-ETHYLUREA is extremely unstable at high pH. It will decompose to extremely unstable decomposition products if acidic conditions are not maintained. When heated to decomposition it emits toxic fumes of nitrogen oxides. Decomposition products may be explosive.
Fire Hazard
Flash point data for N-NITROSO-N-ETHYLUREA are not available; however, N-NITROSO-N-ETHYLUREA is probably combustible.
Biochem/physiol Actions
DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
Potential Exposure
Used as a chemical intermediate for dyes and pharmaceuticals; a polymerization inhibitor during the manufacture of vinyl monomers such as styrene; a precursor of diazoethane; accelerator for rubber vulcanization.
Carcinogenicity
N-Nitroso-N-ethylurea is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping
Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
Incompatibilities
N-nitroso-N-ethylurea is highly reactive. Sensitive to moisture and light. Its stability in aqueous solutions is pH-dependent. Incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly explosive gas. This compound is extremely unstable at high pH. It will decompose to extremely unstable decomposition products if acidic conditions are not maintained. Nitrated organics range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction. Reaction with
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
N-NITROSO-N-ETHYLUREA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| RR Scientific LLC | +86-13917743231 | sales@rrscientific.com | United States | 878 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 7433 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |