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PP242

PP242 structure

CAS No.: 1092351-67-1

Chemical Name:: PP242

Synonyms: PP242;CS-19;Torkinib;PP242, >=98%;PP242;PP-242;PP242 USP/EP/BP;PP242 (Torkinib);Torkinib (PP242);PP242, Free Base;TORKINIB;PP242; PP-242;PP 242

CBNumber:: CB92518269

Molecular Formula:: C16H16N6O

Molecular Weight:: 308.34

MDL Number:: MFCD12196869

MOL File:: 1092351-67-1.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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PP242 Properties

Melting point	>187°C (dec.)
Boiling point	642.0±50.0 °C(Predicted)
Density	1.55
Flash point	342.097℃
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	White powder solid.
pka	9.51±0.40(Predicted)
color	Pale Brown to Light Brown
FDA UNII	H5669VNZ7V

SAFETY

Risk and Safety Statements

HS Code	29339900

PP242 price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	13643	PP242 ≥95%	1092351-67-1	1mg	$32	2024-03-01	Buy
Cayman Chemical	13643	PP242 ≥95%	1092351-67-1	5mg	$82	2024-03-01	Buy
Cayman Chemical	13643	PP242 ≥95%	1092351-67-1	10mg	$133	2024-03-01	Buy
Cayman Chemical	13643	PP242	1092351-67-1	25mg	$290	2024-03-01	Buy
Tocris	4257	PP242 ≥98%(HPLC)	1092351-67-1	25	$514	2021-12-16	Buy

Product number	Packaging	Price	Buy
13643	1mg	$32	Buy
13643	5mg	$82	Buy
13643	10mg	$133	Buy
13643	25mg	$290	Buy
4257	25	$514	Buy

PP242 Chemical Properties,Uses,Production

Description

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin) and regulate different pathways. PP242 is an inhibitor of the active site of mTOR kinase in both mTORC1 and mTORC2 (IC₅₀ = 8 nM). It less effectively inhibits PKCα, PI3-kinase subunit p110γ, JAK2, PKCβI, and PKCβII (IC₅₀ = 49, 102, 110, 198, and 185, respectively). PP242 has been shown to cause the death of certain human and murine leukemia cells more potently than rapamycin and, in vivo, delays leukemia onset and augments the effects of tyrosine kinase inhibitors in suppressing leukemic expansion and extending survival.

Uses

PP 242 is used in leukemia therapy suppressing mTOR signaling. Dual mTORC1/C2 inhibitor.

Definition

ChEBI: A member of the class of pyrazolopyrimidines that is 1H-pyrazolo[3,4-d]pyrimidine substituted by isopropyl, 5-hydroxyindol-2-yl and amino groups at positions 1, 3 and 4 respectively. It is a potent inhibitor of mTOR and exhi its anti-cancer properties.

Enzyme inhibitor

This ATP-competitive mTORC1/mTORC2 inhibitor (FW = 308.34 g/mol; CAS 1092351-67-1; Solubility: 25 mM in DMSO), also named 2-[4-amino- 1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol, has a IC50 = 8 nM for both isoforms of mammalian target of rapamycin (mTOR), also known as FK506-binding protein 12-rapamycin-associated protein 1, or FRAP1, a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. PP-242 shows considerable selectivity for mTOR versus PI3K family kinases. In models of acute leukemia harboring the Philadelphia chromosome (Ph) translocation, PP242, but not rapamycin, causes death of mouse and human leukemia cells. Indeed, PP242 completely inhibits TORC1 and TORC2 signaling in BCR-ABL+ cells, whereas rapamycin partially suppresses TORC1 and drives a PI3K/AKT surge. Moreover, PP242 augments TNF-related apoptosis-inducing ligand- (TRAIL-) induced apoptosis in NSCLC cells, indicating that mTORC2 regulates Cbl-dependent FLIPS degradation and TRAIL-induced apoptosis Other Targets: p110γ (IC50 = 0.102 μM); DNA-PK ((IC50 = 0.408 μM); p110δ ((IC50 = 1.27 μM); p110α ((IC50 = 1.96 μM), and p110β ((IC50 = 2.2 μM), with much weaker inhibition of 215 other kinases.

storage

Store at +4°C

PP242 Preparation Products And Raw materials

Raw materials

Preparation Products

PP242 Suppliers

Global( 174)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58

View Lastest Price from PP242 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	PP242 1092351-67-1	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

PP242
1092351-67-1
US $2.00 / kg
99%
Career Henan Chemical Co

PP242 Spectrum

PP242(1092351-67-1)¹HNMR

1092351-67-1(PP242)Related Search:

PP1 PP2 USP/EP/BP Y27632 (hydrochloride) AZD-8055 MK-2206 2HCl

WORTMANNIN Torin 1 Rapamycin

1of2

PP242 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol PP242, Free Base Torkinib 1H-Indol-5-ol, 2-[4-aMino-1-(1-Methylethyl)-1H-pyrazolo[3,4-d]pyriMidin-3-yl]- Torkinib (PP242) 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol PP 242 PP242, >=98% pp242, 2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol PP242;PP-242 PP242 (Torkinib) TORKINIB;PP242; PP-242;PP 242 CS-19 (2E)-2-(4-amino-1-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene)indol-5-ol 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol/PP242 PP242 USP/EP/BP PP242 mTOR inhibitor ab141405 PP-242 1092351-67-1 Akt mTOR PI3K Inhibitors Antineoplastic PI3K/Akt/mTOR