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IWP L6

IWP L6 structure

CAS No.: 1427782-89-5

Chemical Name:: IWP L6

Synonyms: IWP L6;CS-1445;IWP-L6, >=98%;IWP L6 USP/EP/BP;Porcn Inhibitor III;PORCN INHIBITOR III;IWP-L6;IWP L 6,inhibit,IWP L6,Porcupine,Inhibitor,IWP L-6,Porcn?Inhibitor?III;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide

CBNumber:: CB92666562

Molecular Formula:: C25H20N4O2S2

Molecular Weight:: 472.58

MDL Number:: MFCD27937771

MOL File:: 1427782-89-5.mol

Last updated:2023-06-30 15:45:59

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IWP L6 Properties

storage temp.	Store at -20° C
solubility	≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form	solid

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

NFPA 704

	0
2		0

IWP L6 price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	5.04819	Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem	1427782-89-5	10MG	$280	2024-03-01	Buy
Cayman Chemical	15243	IWP-L6 ≥98%	1427782-89-5	5mg	$82	2024-03-01	Buy
Cayman Chemical	15243	IWP-L6 ≥98%	1427782-89-5	10mg	$153	2024-03-01	Buy
Cayman Chemical	15243	IWP-L6 ≥98%	1427782-89-5	50mg	$561	2024-03-01	Buy
Tocris	4992	IWPL6 ≥98%(HPLC)	1427782-89-5	10	$189	2021-12-16	Buy

Product number	Packaging	Price	Buy
5.04819	10MG	$280	Buy
15243	5mg	$82	Buy
15243	10mg	$153	Buy
15243	50mg	$561	Buy
4992	10	$189	Buy

IWP L6 Chemical Properties,Uses,Production

Uses

2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide is an inhibitor of Porcupine, a member of the membrane-bound O-acyltransferase family of proteins.

Biological Activity

iwp-l6 is an inhibitor of porcupine with ic50 value of 0.5nm [1].iwp-l6 is developed as a sub-nanomolar inhibitor.of porcupine. it targets the wnt signaling since porcupine is the enzyme to catalyze the palmitoylation of wnt proteins. in hek293 cells, iwp-l6 is found to inhibi the phosphorylation of dishevelled 2 (dvl2) significantly. iwp-l6 has good stability in human plasma but weaker stability in rat and mouse plasma. in vivo assay shows that iwp-l6 is quite active in zebrafish. it blocks the regeneration of the tailfin effectively. it also shows inhibition of posterior axis formation at low micromolar concentrations. additionally, in cultured mouse embryonic kidneys, 10nm iwp-l6 can significantly reduce branching morphogenesis while 50nm iwp-l6 completely blocks wnt signaling [1].

storage

+4°C

References

[1] wang x, moon j, dodge me, pan x, zhang l, hanson jm, tuladhar r, ma z, shi h, williams ns, amatruda jf, carroll tj, lum l, chen c. the development of highly potent inhibitors for porcupine. j med chem. 2013 mar 28;56(6):2700-4.

IWP L6 synthesis

Synthesis of IWP L6 from 2-Thiophenecarboxylicacid,3-amino-4,5-dihydro-,methylester(9CI)

IWP L6 Preparation Products And Raw materials

Raw materials

Preparation Products

IWP L6 Suppliers

Global( 75)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	27486	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

View Lastest Price from IWP L6 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-02	2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide 1427782-89-5	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide
1427782-89-5
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

IWP L6 Spectrum

IWP L6(1427782-89-5)¹HNMR

1427782-89-5(IWP L6)Related Search:

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ML-323

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IWP L6 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyriMidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetaMide N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide Porcn Inhibitor III N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide IWP-L6 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide IWP-L6, >=98% 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl CS-1445 PORCN INHIBITOR III;IWP-L6 Acetamide, N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]- IWP L6 USP/EP/BP IWP L 6,inhibit,IWP L6,Porcupine,Inhibitor,IWP L-6,Porcn?Inhibitor?III 1427782-89-5 Inhibitors