Ibrutinib Impurity 13

Ibrutinib Impurity 4 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine Ibrutinib Impurity 6 Ibrutinib Impurity 12 Ibrutinib Impurity 3

(S)-1-Boc-3-hydroxypiperidine Ibrutinib Impurity 14 (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-chloropropan-1-one Ibrutinib Impurity 11 Ibrutinib Impurity 2

Ibrutinib Impurity 9 Ibrutinib Ibrutinib Impurity 10 1-Piperidinecarboxylic acid, 3-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-, 1,1-diMethylethyl ester, (3R)-