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5-Bromo-2-chlorobenzoic acid

5-Bromo-2-chlorobenzoic acid structure

CAS No.: 21739-92-4

Chemical Name:: 5-Bromo-2-chlorobenzoic acid

Synonyms: BCBA;2-CHLORO-5-BROMOBENZOIC ACID;5-Br-2-CI Benzoic acid;5-bromo-2-chlorobenzoate;5-Bromo-2-chlorobenzoicaci;Empagliflozin Impurity 182;5-BROMO-2-CHLOROBENZOIC ACID;2-chloro 5-bromo bezoic acid;5-Bromo-2-Chlorobenzoci Acid;5-Bromo-2-chlorobenzoic(BCBA)

CBNumber:: CB9669275

Molecular Formula:: C7H4BrClO2

Molecular Weight:: 235.46

MDL Number:: MFCD00002415

MOL File:: 21739-92-4.mol

MSDS File:: SDS

Last updated:2024-09-05 22:20:32

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5-Bromo-2-chlorobenzoic acid Properties

Melting point	154-156 °C (lit.)
Boiling point	324.5±27.0 °C(Predicted)
Density	1.7312 (rough estimate)
refractive index	1.5590 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	2.63g/l
pka	2.49±0.25(Predicted)
form	Solid
color	Off white colored powder
Water Solubility	Soluble in water 2.63 g/L @20°C.
BRN	2691432
InChI	InChI=1S/C7H4BrClO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)
InChIKey	FGERXQWKKIVFQG-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC(Br)=CC=C1Cl
CAS DataBase Reference	21739-92-4(CAS DataBase Reference)
NIST Chemistry Reference	5-Bromo-2-chlorobenzoic acid(21739-92-4)
EPA Substance Registry System	Benzoic acid, 5-bromo-2-chloro- (21739-92-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

HazardClass

IRRITANT

HS Code

29163900

NFPA 704

	0
2		0

5-Bromo-2-chlorobenzoic acid price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	175544	5-Bromo-2-chlorobenzoic acid 98%	21739-92-4	25g	$18.72	2024-03-01	Buy
Sigma-Aldrich	175544	5-Bromo-2-chlorobenzoic acid 98%	21739-92-4	100g	$36.84	2024-03-01	Buy
TCI Chemical	B1344	5-Bromo-2-chlorobenzoic Acid >98.0%(GC)(T)	21739-92-4	10g	$32	2024-03-01	Buy
TCI Chemical	B1344	5-Bromo-2-chlorobenzoic Acid >98.0%(GC)(T)	21739-92-4	25g	$78	2024-03-01	Buy
Alfa Aesar	A12218	5-Bromo-2-chlorobenzoic acid, 98+%	21739-92-4	10g	$39.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
175544	25g	$18.72	Buy
175544	100g	$36.84	Buy
B1344	10g	$32	Buy
B1344	25g	$78	Buy
A12218	10g	$39.65	Buy

5-Bromo-2-chlorobenzoic acid Chemical Properties,Uses,Production

Description

5-Bromo-2-chlorobenzoic acid (BCBA) is an organic reagent that can be used in electroinduced dehalogenation reactions. Ag/Cu electrodes exhibit high electrocatalytic activity in the dehalogenation reaction of BCBA. The process is characterised by a sequence of halide excretion and hydrogen addition. Since the bond dissociation energy value of C-Br bond is smaller than that of C-Cl bond, Br-w is more easily released from the benzene ring. As C-Br breaks, BCBA gains electrons and hydrogen to form the intermediate 2-chlorobenzoate. C-Cl then breaks in the same way to give the final product benzoate.

Chemical Properties

white to light yellow crystal powder

Uses

5-Bromo-2-chlorobenzoic acid was used to evaluate the homogeneity of organic powder. It can be used to produce 2-chloro-5-deuteriobenzoic acid.

Synthesis

4.7g (0.03 mol) of 2-chlorobenzoic acid, 40mL of concentrated sulfuric acid and 0.936g (0.012 mol) of sodium sulfide are sequentially added into a 250mL four-mouth bottle, stirred for 20 minutes at 30 ℃ until the solution is clear, then 5.334g N-bromosuccinimide (0.03 mol) is added, the reaction is continued for 10 minutes at 30 ℃, and then the solution is slowly poured into 80mL ice water bath for crystallization to obtain a crude product of the 5-bromo-2-chlorobenzoic acid. Add the filter cake into a 250mL four-mouth bottle, add 24mL methanol and 36mL water, heat to 60 ℃, naturally cool, and stir for crystallization. Filtration, washing with 20mL of 40% volume fraction aqueous methanol, and drying at 55 ℃ for 6 hours gave 6.001g of a white solid, yield: 85.0%.

5-Bromo-2-chlorobenzoic acid synthesis

Synthesis of 5-Bromo-2-chlorobenzoic acid from 5-Bromo-2-chlorobenzonitrile

5-Bromo-2-chlorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

5'-BROMO-2'-CHLOROACETOPHENONE 5-BROMO-2-CHLORO-BENZOYL CHLORIDE Bexagliflozin ETHYL 5-BROMO-2-CHLOROBENZOATE 4-(5-broMo-2-chlorobenzyl)phenol

2-(5-Bromo-2-chloro-phenyl)-1H-benzoimidazole (5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone 5-Bromo-2-chloro-N-cyclopropylbenzamide [1,1'-Biphenyl]-3-carboxylic acid, 4-chloro-3'-fluoro- 2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid

(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(methoxy) methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone

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5-Bromo-2-chlorobenzoic acid Suppliers

Global( 763)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Nordica Biopharma CO.,LTD	+8618136148818	anna.ran@nordicabio.com	China	298	58
Shanghai Yongzeng Technology Co.,Ltd	+86-021-65281118 +86-13818947575	sales@yongzchem.com	China	133	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12446	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5873	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5872	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20293	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	973	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29798	60

Supplier	Advantage
Suzhou Nordica Biopharma CO.,LTD	58
Shanghai Yongzeng Technology Co.,Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Changzhou Rokechem Technology Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60

View Lastest Price from 5-Bromo-2-chlorobenzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-09-20	5-Bromo-2-chlorobenzoic acid 21739-92-4	US $75.00 / KG	1KG	98%	20 tons	Speranza Chemical Co., Ltd.
2024-09-20	5-Bromo-2-chlorobenzoic acid 21739-92-4	US $12.00 / KG	1KG	99%	200mt/year	Jinan Finer Chemical Co., Ltd
2024-09-20	5-Bromo-2-chlorobenzoic acid 21739-92-4	US $13.00 / KG	1KG	99%	100mt	Jinan Finer Chemical Co., Ltd

5-Bromo-2-chlorobenzoic acid
21739-92-4
US $75.00 / KG
98%
Speranza Chemical Co., Ltd.

5-Bromo-2-chlorobenzoic acid
21739-92-4
US $12.00 / KG
99%
Jinan Finer Chemical Co., Ltd

5-Bromo-2-chlorobenzoic acid
21739-92-4
US $13.00 / KG
99%
Jinan Finer Chemical Co., Ltd

5-Bromo-2-chlorobenzoic acid Spectrum

5-Bromo-2-chlorobenzoic acid(21739-92-4)MS 5-Bromo-2-chlorobenzoic acid(21739-92-4)¹HNMR 5-Bromo-2-chlorobenzoic acid(21739-92-4)¹³CNMR 5-Bromo-2-chlorobenzoic acid(21739-92-4)IR1 5-Bromo-2-chlorobenzoic acid(21739-92-4)IR2 5-Bromo-2-chlorobenzoic acid(21739-92-4)Raman

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Benzoic acid, 5-bromo-2-chloro- 5-Bromo-2-chlorobenzoic acid, 98+% 5-BROMO-2-CHLOROBENZOIC ACID 5-Bromo-2-Chlorobenzoic Acid (BCBA) 5-Bromo-2-chlorobenzoic acid ,99% 5-BROMO-2-CHLOROBENZOIC ACID FOR SYNTHES 5 - broMine - 2 - chlorobenzoic acid 5-Bromo-2-chlorobenzoic acid 97+% 5-Bromo 2-Chloro Benzoic Acid CAS NO 21739-92-4 5-bromo-2-chlorobenzoate Benzoic acid, 5-bromo-2-chloro- BCBA 5-Bromo-2-chlorobenzoic Acid > 5-Bromo-2-chlorobenzoicaci 5-Bromo-2-chlorobenzoic acid CAS 21739 92 4 2-chloro 5-bromo bezoic acid 5-Bromo-2-chlorobenzoic(BCBA) 2-CHLORO-5-BROMOBENZOIC ACID BCBA Dapagliflozin Intermediate/ Empagliflozin Intermediate/ 5-Bromo-2-Chlorobenzoic Acid China biggest manufacturer 5-Bromo-2-chlorobenzoic acid 21739-92-4 5-Br-2-CI Benzoic acid Empagliflozin Impurity 182 5-Bromo-2-Chlororbenzoic acid (BCBA) 5-Bromo-2-Chlorobenzoci Acid 5-Bromo-2-ChIoro Benzoic Acid 21739-92-4 1739-92-4 21739-29-4 C7H3BrClO2 Building Blocks Carboxylic Acids Carbonyl Compounds C7 Organic Building Blocks Building Blocks Carbonyl Compounds Carboxylic Acids Chemical Synthesis Organic Building Blocks C7 Carbonyl Compounds Carboxylic Acids Benzoic acid series Organic acids Miscellaneous Acids & Esters Bromine Compounds Chlorine Compounds blocks Bromides Carboxes Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid bc0001 21739-92-4 john's