Propyl chloroformate
- CAS No.
- 109-61-5
- Chemical Name:
- Propyl chloroformate
- Synonyms
- NPCF;propyl carbonochloridate;PROPYL CHLOROCARBONATE;Propyl chloroforMat;PROPYL CHLOROFORMATE;Proply chloroformate;N-PROPYL CHLOROFORMATE;Chloride propyl forMate;Propyl chloridocarbonate;n-Propyl chlorocarbonate
- CBNumber:
- CB9852781
- Molecular Formula:
- C4H7ClO2
- Molecular Weight:
- 122.55
- MDL Number:
- MFCD00000649
- MOL File:
- 109-61-5.mol
| Boiling point | 105-106 °C(lit.) |
|---|---|
| Density | 1.09 g/mL at 25 °C(lit.) |
| vapor pressure | 0.87 psi ( 20 °C) |
| refractive index |
n |
| Flash point | 84 °F |
| storage temp. | 2-8°C |
| solubility | benzene: miscible(lit.) |
| form | Oil |
| color | Colourless |
| Specific Gravity | 1.09 |
| Merck | 13,7940 |
| Dielectric constant | 11.2（20℃） |
| Stability | Volatile |
| InChIKey | QQKDTTWZXHEGAQ-UHFFFAOYSA-N |
| LogP | 1.385 (est) |
| CAS DataBase Reference | 109-61-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | A5Y2T003JU |
| NIST Chemistry Reference | n-Propylchloroformate(109-61-5) |
| EPA Substance Registry System | Propyl chloroformate (109-61-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H302-H314-H331 |
| Precautionary statements | P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T,F |
| Risk Statements | 10-23-34-22-11 |
| Safety Statements | 26-36-45-16 |
| RIDADR | UN 2740 6.1/PG 1 |
| WGK Germany | 1 |
| RTECS | LQ6830000 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| HS Code | 29151300 |
| Toxicity | mouse,LC50,inhalation,319ppm/1H (319ppm),"Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds. New York, John Wiley & Sons, Inc., 1978Vol. 4, Pg. 758, 1978. |
Propyl chloroformate price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 249467 | Propyl chloroformate 98% | 109-61-5 | 25g | $45.3 | 2023-01-07 | Buy |
| Sigma-Aldrich | 249467 | Propyl chloroformate 98% | 109-61-5 | 100g | $129 | 2023-01-07 | Buy |
| TRC | P835120 | Propyl chloroformate | 109-61-5 | 5g | $110 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0026913 | N-PROPYL CHLOROFORMATE 95.00% | 109-61-5 | 25G | $1129.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0026913 | N-PROPYL CHLOROFORMATE 95.00% | 109-61-5 | 100G | $2539.13 | 2021-12-16 | Buy |
Propyl chloroformate Chemical Properties,Uses,Production
Chemical Properties
Propyl Chloroformate (PCF) is a colorless to yellow liquid, with a pungent odor. It reacts with water and spontaneous decomposes. It is miscible with benzene and ether.
Uses
Propyl Chloroformate is used as a dramatizing agent for the determination of morphine, codeine and 6-acetyl morphine in urine and blood using direct aqueous derivatization.
Production Methods
Prepared by the reaction of liquid anhydrous n-propyl alcohol with molar excess of dry, chlorine-free phosgene at low temperature.
Application
Propyl chloroformate has been used:
as derivatization reagent in quantification of dopamine, serotonin and norepinephrine in human urine by solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry
in the preparation of dipropyl 3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazine-1,2-dicarboxylate
N-propyl chloroformate is an intermediate of the fungicide propamocarb.
Preparation
Synthesis of Propyl chloroformate: Add n-propanol to the phosgene-passing kettle, start stirring, and then pass phosgene through the phosgene flowmeter. The phosgene-passing temperature is about 30 °C, and continue to pass the phosgene for several hours. When the end point is approached, sample and analyze, and stop when the standard is reached. Pass phosgene, cool, and then pass nitrogen to drive away phosgene and hydrogen chloride, destroy phosgene, and sample and analyze it as a product.
Reaction equation: CH3CH2CH2OH+COCl2→ClCOOCH2CH2CH3
General Description
N-propyl chloroformate appears as a colorless liquid. May be decomposed by water. Severely irritates skin and eyes. Very toxic by ingestion, inhalation or skin absorption. Denser than water and vapors heavier than air. Flash point 50°F. Used to make other chemicals.
Air & Water Reactions
Highly flammable. Water (moisture in air or soil) reacts with generation of heat and hydrochloric acid.
Reactivity Profile
Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air. [EPA, 1998]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
Strongly irritating to eyes and mucous membranes. Poisonous; may be fatal if inhaled, swallowed or absorbed through skin.
Fire Hazard
When heated to decomposition, Propyl chloroformate emits toxic fumes of chlorine containing compounds. Propyl chloroformate is a flammable/combustible material; Propyl chloroformate may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat or fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Runoff from fire control or dilution water may cause pollution. Gradually decomposed by water and alcohol. Unstable, decomposes spontaneously to form hydrochloric acid and other products. Avoid moist air.
Flammability and Explosibility
Flammable
Safety Profile
Poison by skin contact. Moderately toxic by ingestion and inhalation. A corrosive irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat or flame, can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Cl-. Used as a reactive intermediate to polymerization initiators.
Potential Exposure
Propyl chloroformate is used in organic synthesis; as an intermediate for polymerization initiators; may have been used as a military poison gas.
Shipping
UN2740 n-Propyl chloroformate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, 8-Corrosive material. Inhalation Hazard Zone B
Incompatibilities
Propyl chloroformate forms explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, water and alcohols. Reaction with water forms heat and hydrochloric acid. Attacks some metals and coating in the presence of moisture.
Propyl chloroformate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Shanghai Yudiao Chemistry Technology Co.,Ltd | 02137285211 18964703211 | info@yudiaochem.com | CHINA | 238 | 58 |
View Lastest Price from Propyl chloroformate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Propyl chloroformate
109-61-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Propyl chloroformate
109-61-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-02 | Propyl chloroformate
109-61-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
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- Propyl chloroformate
109-61-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Propyl chloroformate
109-61-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Propyl chloroformate
109-61-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd