NNMTi 化学特性,用途語,生産方法
説明
NNMTi (CAS 42464-96-0) is a nicotinamide N-methyltransferase (NNMT) inhibitor that promotes myoblast differentiation. NNMT is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. NNMTi treatment combined with lean diet substitution accelerated improved body weight fat loss, increased whole-body lean mass to body weight ratio, reduced liver epididymal white adipose tissue weights, decreased liver adiposity, improved hepatic steatosis, relative to a lean diet substitution alone.
化学的特性
Brown solid.
使用
NNMTi is an enzyme overexpressed during skeletal muscle aging and is associated with the repair of damage to the NAD+ pathway, dysregulation of sirtuin1 activity, and increased senescence of muscle stem cells.
製造方法
Synthesis of 5-Amino-1-methyl-1-quinolinium Iodide(NNMTi): Iodomethane (0.160 ml, 0.365 g, 2.6 mmol) was added to a solution of 5-aminoquinoline (0.277 g, 1.9 mmol) in tetrahydrofuran (7 ml), and stirred at room temperature for 1 day until a red solid precipitated. After filtration, the filter cake was washed with tetrahydrofuran (2 x 5 ml) and dried under vacuum to give 0.240 g of compound 5-Amino-1-methyl-1-quinolinium Iodide.
参考文献
[1]. Harshini Neelakantan, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492. DOI:
10.1016/j.bcp.2019.02.008[2]. Harshini Neelakantan, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem DOI:
10.1021/acs.jmedchem.7b00389[3]. Mark A Eckert et al. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature, 569(7758), 723-728 (2019-05-03) DOI:
10.1038/s41586-019-1173-8[4]. SAMPSONCATHERINE M. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice.[J]. Scientific Reports, 2021: 5637. DOI:
10.1038/s41598-021-85051-6.
NNMTi 上流と下流の製品情報
原材料
準備製品