TRIMIDOX 化学特性,用途語,生産方法
説明
Ribonucleotide reductase, the rate-
limiting enzyme for
de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-
60 cells, inducing apoptosis
via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-
60 cells with an IC
50 value of 35 μM.
使用
Trimidox is a specific ribonucleotide reductase inhibitor.
TRIMIDOX 上流と下流の製品情報
原材料
準備製品