T16AINH-A01
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- CAS番号.
- 552309-42-9
- 化学名:
- T16AINH-A01
- 别名:
- T16AINH-A01;2-[(5-エチル-1,6-ジヒドロ-4-メチル-6-オキソ-2-ピリミジニル)チオ]-N-[4-(4-メトキシフェニル)-2-チアゾリル]アセトアミド;N-[4-(4-メトキシフェニル)-2-チアゾリル]-2-[(5-エチル-6-メチル-4-オキソ-1,4-ジヒドロピリミジン-2-イル)チオ]アセトアミド;N-[4-(4-メトキシフェニル)チアゾール-2-イル]-2-(4-ヒドロキシ-5-エチル-6-メチルピリミジン-2-イルチオ)アセトアミド;2-[(5-エチル-1,6-ジヒドロ-4-メチル-6-オキソピリミジン-2-イル)チオ]-N-[4-(4-メトキシフェニル)-2-チアゾリル]アセトアミド;2-[(5-エチル-4-ヒドロキシ-6-メチルピリミジン-2-イル)スルファニル]-N-[4-(4-メトキシフェニル)-1,3-チアゾール-2-イル]アセトアミド
- 英語名:
- TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01)
- 英語别名:
- T16Ainh-A01;inhibitor of TMEM16A;TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01);TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem;inhibit,T16AinhA01,Chloride Channel,T16Ainh-A01,T-16Ainh-A01,T16Ainh A01,Cl-Channels,Inhibitor;2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide;2-((5-Ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide;Acetamide, 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-
- CBNumber:
- CB32630099
- 化学式:
- C19H20N4O3S2
- 分子量:
- 416.52
- MOL File:
- 552309-42-9.mol
- MSDS File:
- SDS
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T16AINH-A01 物理性質
- 融点 :
- 211-212°C (dec.)
- 比重(密度) :
- 1.39±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- room temp
- 溶解性:
- DMSO:可溶5mg/mL、透明(加温)
- 酸解離定数(Pka):
- 7.20±0.50(Predicted)
- 外見 :
- 粉
- 色:
- 白からベージュ
T16AINH-A01 価格
もっと(7)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC4538 |
T16Ainh-A01
T16Ainh - A01 |
552309-42-9 |
10mg |
¥56000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC4538 |
T16Ainh-A01
T16Ainh - A01 |
552309-42-9 |
50mg |
¥235000 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
SML0493 |
≥95% (HPLC)
T16Ainh-A01 ≥95% (HPLC) |
552309-42-9 |
10mg |
¥16100 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
SML0493 |
≥95% (HPLC)
T16Ainh-A01 ≥95% (HPLC) |
552309-42-9 |
50mg |
¥80900 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCE917355 |
2-[(5-エチル-1,6-ジヒドロ-4-メチル-6-オキソ-2-ピリミジニル)チオ]-N-[4-(4-メトキシフェニル)-2-チアゾリル]アセトアミド
2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide |
552309-42-9 |
10mg |
¥16500 |
2024-03-01 |
購入 |
T16AINH-A01 化学特性,用途語,生産方法
使用
TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01) compound functions as a selective class A inhibitor of the calcium activated chloride channel TMEM16A. Useful in the treatment of hypertension, pain, diarrhea and mucus overproduction.
一般的な説明
An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC
50 = 1.1 μM). Fully blocks CaCC current in salivary gland cells at 10 μM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No.
631547) at 10 μM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
Biochem/physiol Actions
T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance.
T16AINH-A01 上流と下流の製品情報
原材料
準備製品
T16AINH-A01 生産企業
Global( 70)Suppliers
T16AINH-A01 スペクトルデータ(1HNMR)
- 552309-42-9
- TMEM16AInhibitorsRevealTMEM16A(T16Ainh-A01)
- T16Ainh-A01
- 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide
- TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem
- Acetamide, 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-
- inhibitor of TMEM16A
- 2-((5-Ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide
- inhibit,T16AinhA01,Chloride Channel,T16Ainh-A01,T-16Ainh-A01,T16Ainh A01,Cl-Channels,Inhibitor
- T16AINH-A01
- 2-[(5-エチル-1,6-ジヒドロ-4-メチル-6-オキソ-2-ピリミジニル)チオ]-N-[4-(4-メトキシフェニル)-2-チアゾリル]アセトアミド
- N-[4-(4-メトキシフェニル)-2-チアゾリル]-2-[(5-エチル-6-メチル-4-オキソ-1,4-ジヒドロピリミジン-2-イル)チオ]アセトアミド
- N-[4-(4-メトキシフェニル)チアゾール-2-イル]-2-(4-ヒドロキシ-5-エチル-6-メチルピリミジン-2-イルチオ)アセトアミド
- 2-[(5-エチル-1,6-ジヒドロ-4-メチル-6-オキソピリミジン-2-イル)チオ]-N-[4-(4-メトキシフェニル)-2-チアゾリル]アセトアミド
- 2-[(5-エチル-4-ヒドロキシ-6-メチルピリミジン-2-イル)スルファニル]-N-[4-(4-メトキシフェニル)-1,3-チアゾール-2-イル]アセトアミド