4-エチル-1,2-ジヒドロ-2-(1-メチルピペリジン-4-イル)-5-フェニル-3H-ピラゾール-3-オン 化学特性,用途語,生産方法
Originator
Palerol, Novartis
Manufacturing Process
A mixture of 8.8 parts of α-ethylbenzoylacetic acid ethyl ester and 5,3 parts of N-methyl-piperidyl-4-hydrazine is allowed to stand for 30 min at 22°C, after which the mixture is heated for 5 hours to 130°C under a pressure of 12 mm. After 4 hours 1-(N-methylpiperidyl-4)-3-phenyl-4-ethylpyrazolone-5 begins crystallize out. The reaction mixture is allowed to cool, after which the crystal mass is triturated with ether and then recrystallized from methanol-ether or from acetone. Melting point 159-161°C.
Therapeutic Function
Analgesic
4-エチル-1,2-ジヒドロ-2-(1-メチルピペリジン-4-イル)-5-フェニル-3H-ピラゾール-3-オン 上流と下流の製品情報
原材料
準備製品