ボクロスポリン

ボクロスポリン 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

ボクロスポリン 化学特性,用途語,生産方法

効能

免疫抑制薬, カルシニューリン阻害薬

説明

Voclosporin, a structurally similar analogue of cyclosporin A, is a new type of calcineurin inhibitor. It has been modified to increase its activity by 3-4 times and exhibits a dual and synergistic mechanism. This drug works by blocking the expression of IL-2 and T cell-mediated immune response, stabilizing renal podocytes. Compared to cyclosporin, voclosporin has the advantage of having less impact on cholesterol and triglycerides and a lower risk of diabetes. In February 2021, vorcyclosporine was approved by the FDA for use in combination immunosuppressive regimens in adult patients with active, lupus nephritis.

定義

ChEBI: Voclosporin is a homodetic cyclic peptide. It is a semi-synthetic calcineurin (CN) inhibitor that exhibits potent immunosuppressive activity.

臨床応用

Voclosporin (Lupkynis(TM)) is an oral calcineurin inhibitor immunosuppressant that is being developed by Aurinia Pharmaceuticals. In January 2021, based on positive results from the pivotal phases II and III trials, oral voclosporin received its first approval in the USA for use in combination with a background immunosuppressive therapy regimen for adults with active lupus nephritis.

参考文献

1. Voclosporin: First Approval DOI: 10.1007/s40265-021-01488-z
2. Voclosporin: A Novel Calcineurin Inhibitor for the Treatment of Lupus Nephritis DOI: 10.1177/10600280221075331

ボクロスポリン 上流と下流の製品情報

原材料

準備製品

ボクロスポリン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28455	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Wuhan Demeikai Biotechnology Co., Ltd	+8618942921723	info@dmksw.xin	China	723	58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.	+86-029-86185165 +8618629664246	guoyuan@eastchinapharm.com	China	1615	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Jiangsu shring Biopharma Co., Ltd.	+8613372282299	sales@shringchem.com	China	3545	58
Shanghai Minkai Biological Technology Co., Ltd	021-52919136 17315815539	2804155403@qq.com	China	169	58

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• 515814-01-4
• Isatx 247
• Isatx247
• Isatx-247
• Luveniq
• Lx211
• R 1524
• Voclosporin
• Voclosporin [usan]
• Cyclosporin A, 6-[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]-
• Voclosporin USP/EP/BP
• Voclosporine
• Voclosporin (ISAtx-247)
• ボクロスポリン
• (2S,5R,8S,11S,14S,17S,20S,26S,29S,32S)-8,11,26,32-テトライソブチル-20-エチル-14,29-ジイソプロピル-2,5,7,10,13,16,22,25,31-ノナメチル-17-[(1R,2R,4E)-1-ヒドロキシ-2-メチル-4,6-ヘプタジエニル]-1,4,7,10,16,19,22,25,28,31-デカアザシクロトリトリアコンタン-3,6,9,12,15,18,21,24,27,30,33-ウンデカオン
• (3S,6R,9S,12S,15S,18S,24S,27S,30S,33S)-24-エチル-27-[(1R,2R,4E)-1-ヒドロキシ-2-メチルヘプタ-4,6-ジエン-1-イル]-1,4,6,9,13,19,22,28,31-ノナメチル-3,12,18,33-テトラキス(2-メチルプロピル)-15,30-ビス(プロパン-2-イル)-1,4,7,10,13,16,19,22,25,28-デカアザシクロトリトリアコンタン-2,5,8,11,14,17,20,23,26,29,32-ウンデカオン