보클로스포린[우산]
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![보클로스포린[우산]](CAS/GIF/515814-01-4.gif)
보클로스포린[우산] 속성
- 끓는 점
- 1303.8±65.0 °C(Predicted)
- 밀도
- 1.016±0.06 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- 벤젠(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 13.32±0.70(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
안전
보클로스포린[우산] C화학적 특성, 용도, 생산
개요
Voclosporin, a structurally similar analogue of cyclosporin A, is a new type of calcineurin inhibitor. It has been modified to increase its activity by 3-4 times and exhibits a dual and synergistic mechanism. This drug works by blocking the expression of IL-2 and T cell-mediated immune response, stabilizing renal podocytes. Compared to cyclosporin, voclosporin has the advantage of having less impact on cholesterol and triglycerides and a lower risk of diabetes. In February 2021, vorcyclosporine was approved by the FDA for use in combination immunosuppressive regimens in adult patients with active, lupus nephritis.정의
ChEBI: Voclosporin is a homodetic cyclic peptide. It is a semi-synthetic calcineurin (CN) inhibitor that exhibits potent immunosuppressive activity.Clinical Use
Voclosporin (Lupkynis(TM)) is an oral calcineurin inhibitor immunosuppressant that is being developed by Aurinia Pharmaceuticals. In January 2021, based on positive results from the pivotal phases II and III trials, oral voclosporin received its first approval in the USA for use in combination with a background immunosuppressive therapy regimen for adults with active lupus nephritis.참고 문헌
1. Voclosporin: First Approval DOI: 10.1007/s40265-021-01488-z2. Voclosporin: A Novel Calcineurin Inhibitor for the Treatment of Lupus Nephritis DOI: 10.1177/10600280221075331
보클로스포린[우산] 준비 용품 및 원자재
원자재
준비 용품
보클로스포린[우산] 공급 업체
글로벌( 60)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 27644 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10523 | 58 |
| Wuhan Demeikai Biotechnology Co., Ltd | +8618942921723 |
info@dmksw.xin | China | 723 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 |
guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 |
kathy@hbyinsheng.com | China | 3582 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 |
sales@shringchem.com | China | 3545 | 58 |
| Shanghai Minkai Biological Technology Co., Ltd | 021-52919136 17315815539 |
2804155403@qq.com | China | 169 | 58 |