N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル
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- CAS番号.
- 1216744-19-2
- 化学名:
- N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル
- 别名:
- tert-ブチル 2-{[(4-クロロフェニル)メチル][(5-ニトロチオフェン-2-イル)メチル]アミノ}アセタート;N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル
- 英語名:
- 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
- 英語别名:
- SK4112;SR6452;GSK 4112;GSK4112,SR6452;SR6452; SR-6452; SR 6452;tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate;tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate;1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate;Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester;SR-6452,hepatic damage,HepG2,Apoptosis,mice,Inhibitor,gluconeogenesis,bmal1,HDAC,hepatic gene,probe,Jo2,inhibit,Fas,GSK-4112,SR 6452,GSK4112,transcription,GSK 4112
- CBNumber:
- CB42518693
- 化学式:
- C18H21ClN2O4S
- 分子量:
- 396.89
- MOL File:
- 1216744-19-2.mol
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N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル 物理性質
- 融点 :
- 95 - 96°C
- 沸点 :
- 486.7±45.0 °C(Predicted)
- 比重(密度) :
- 1.296±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- クロロホルム（微量）、メタノール（微量、加温）
- 酸解離定数(Pka):
- 3.87±0.50(Predicted)
- 外見 :
- 粉
- 色:
- オフホワイトからタン
N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC3663 |
GSK 4112 |
1216744-19-2 |
10mg |
￥59000 |
2024-03-01 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC3663 |
GSK 4112 |
1216744-19-2 |
50mg |
￥250000 |
2024-03-01 |
購入 |
N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル 化学特性,用途語,生産方法
使用
GSK 4112 is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
Biochem/physiol Actions
GSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba.
N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル 上流と下流の製品情報
原材料
準備製品
N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル 生産企業
Global( 76)Suppliers
N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル スペクトルデータ(1HNMR)
- 1216744-19-2
- 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
- GSK 4112
- SR6452
- GSK4112,SR6452
- tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate
- SR6452; SR-6452; SR 6452
- tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate
- SK4112
- Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester
- SR-6452,hepatic damage,HepG2,Apoptosis,mice,Inhibitor,gluconeogenesis,bmal1,HDAC,hepatic gene,probe,Jo2,inhibit,Fas,GSK-4112,SR 6452,GSK4112,transcription,GSK 4112
- tert-ブチル 2-{[(4-クロロフェニル)メチル][(5-ニトロチオフェン-2-イル)メチル]アミノ}アセタート
- N-(4-クロロベンジル)-N-(5-ニトロ-2-テニル)グリシンtert-ブチル