プラテンシン

プラテンシン 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

プラテンシン 化学特性,用途語,生産方法

説明

Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC₅₀ values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.

使用

Platencin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Platencin is more potent than its analogue, platensimycin. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, b-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF.

酵素阻害剤

This antibiotic (FW = 425.2 g/mol; CAS 869898-86-2; Soluble in ethanol, methanol, DMF or DMSO) inhibits both Staphylococcus aureus b-ketoacyl- [acyl-carrier-protein] synthases II and III, with IC50 values of 1.95 and 3.91 μg/mL, respectively. Platencin exhibits strong, broad-spectrum, Grampositive antibacterial activity to key antibiotic resistant strains, including methicillin-resistant Staphylococcus aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococcus faecium, without evidence of toxicity in humans.

プラテンシン 上流と下流の製品情報

原材料

準備製品

プラテンシン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	56026	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Meng Cheng Technology (Shanghai) Co., LTD	400-820-6829	sales@mitachieve.com	China	8864	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58

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• 869898-86-2
• Platencin
• Benzoic acid, 3-[[3-[(2S,4aS,8S,8aR)-1,3,4,7,8,8a-hexahydro-8-methyl-3-methylene-7-oxo-2H-2,4a-ethanonaphthalen-8-yl]-1-oxopropyl]amino]-2,4-dihydroxy-
• 2,4-ジヒドロキシ-3-{3-[(1S,5S,6R,8S)-5-メチル-9-メチリデン-4-オキソトリシクロ[6.2.2.01,6]ドデカ-2-エン-5-イル]プロパンアミド}安息香酸
• プラテンシン
• 2,4-ジヒドロキシ-3-[[3-[(1S,5S,6R,8S)-4-オキソ-5-メチル-9-メチレントリシクロ[6.2.2.01,6]ドデカ-2-エン-5-イル]プロピオニル]アミノ]安息香酸
• (-)-プラテンシン
• 2,4-ジヒドロキシ-3-[3-[(1S)-1-メチル-2-オキソ-6-メチレン-4aβ,7β-エタノ-1,2,4a,5,6,7,8,8aα-オクタヒドロナフタレン-1α-イル]プロパノイルアミノ]安息香酸