1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
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- CAS番号.
- 219315-22-7
- 化学名:
- 别名:
- 英語名:
- 1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
- 英語别名:
- Mitochondrial Fusion Promoter M1;Mitochondrial Fusion Promoter M1 >=95% (HPLC);Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem;(E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol;1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone;Ethanone, 1-(5-chloro-2-hydroxyphenyl)-, 2-(2,4,6-trichlorophenyl)hydrazone;Mitochondrial Metabolism,ischemia,cardiac,inhibit,brain,damage,injury,reperfusion,Mitochondrial fusion promoter M 1,Mitochondrial fusion promoter M-1,Mitochondrial fusion promoter M1,Inhibitor
- CBNumber:
- CB42750677
- 化学式:
- C14H10Cl4N2O
- 分子量:
- 364.05
- MOL File:
- 219315-22-7.mol
- MSDS File:
- SDS
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1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone 物理性質
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：可溶10mg/mL、透明
- 外見 :
- 粉
- 色:
- 白からベージュ
- 安定性：:
- -20°C の DMSO またはエタノール溶液で最大 2 か月間保存できます。
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| WGK Germany |
3 |
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| HSコード |
2928009090 |
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| 絵表示（GHS） |
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| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
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P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
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| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
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1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone 価格
もっと(1)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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Sigma-Aldrich Japan
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SML0629 |
≥95% (HPLC)
Mitochondrial Fusion Promoter M1 ≥95% (HPLC) |
219315-22-7 |
25mg |
￥36900 |
2024-03-01 |
購入 |
1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone 化学特性,用途語,生産方法
使用
Mitochondrial Fusion Promoter M1 has been used as a fusion promoter:
- to study its effects on peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α expression in breast cancer cells
- to study the link between nucleoside diphosphate kinase 3 (NME3)-regulated mitochondrial fluctuations and stability of genome in NME3 knockdown cells
- to study its effects on mitochondrial fusion in neuronal cells
一般的な説明
A cell-permeable phenylhydrazone compound that restores mitochondrial tubular network formation from the fragmented mitochondria seen in MEF lacking either one of the two outer mitochondrial membrane (OMM) mitofusins (EC
50 = 5.3 and 4.42 μM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or MPP+-treated SH-SY5Y cells (5 μM 24 h), while displaying no effect on ER or lysosome morphology in Mfn1 knockout MEF. The effect of M1 is limited to enhancing weakened mitochondrial fusion machinery and M1 cannot by itself rebuild interconnected tubular mitochondria in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5 μM 24 h) is reported to boost the downregulated ATP5A and ATP5B protein level in either Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin (Cat. No.
495455) at 5 μM is shown to completely offset the mitochondrial fusion effect by 5 μM M1 in Mfn1 knockout MEF. Both M1 and Z-VAD-FMK (Cat. No.
219007) are shown to protect SH-SY5Y against MPP
+-induced neuronal toxicity and additive protection can be achieved via a combined treatment (62%, 73%, 77%, and 89% survival rate, respectively, with DMSO, 5 μM M1, 1 μM Z-VAD-FMK, and combined treatment). Comparing to mdivi-1 (Cat. No.
475856), M1 exerts its effect via promoting fusion rather than inhibiting fission or division.
Biochem/physiol Actions
Cell permeable: yes
1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone 上流と下流の製品情報
原材料
準備製品
1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone 生産企業
Global( 26)Suppliers
219315-22-7()キーワード:
- 219315-22-7
- (E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol
- 1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone
- Mitochondrial Fusion Promoter M1
- Mitochondrial Fusion Promoter, M1 - CAS 219315-22-7 - Calbiochem
- Ethanone, 1-(5-chloro-2-hydroxyphenyl)-, 2-(2,4,6-trichlorophenyl)hydrazone
- Mitochondrial Fusion Promoter M1 >=95% (HPLC)
- Mitochondrial Metabolism,ischemia,cardiac,inhibit,brain,damage,injury,reperfusion,Mitochondrial fusion promoter M 1,Mitochondrial fusion promoter M-1,Mitochondrial fusion promoter M1,Inhibitor