バリノマイシン

バリノマイシン 価格 もっと(27)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01CAY10009152	Valinomycin	2001-95-8	5mg	￥7000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01CAY10009152	Valinomycin	2001-95-8	10mg	￥12000	2024-03-01	購入
Sigma-Aldrich Japan	94675	バリノマイシン ≥99.0% (TLC) Valinomycin ≥99.0% (TLC)	2001-95-8	10mg	￥17400	2024-03-01	購入
Sigma-Aldrich Japan	60403	カリウムイオノフォアI Selectophore?, function tested Potassium ionophore I Selectophore?, function tested	2001-95-8	100mg	￥91300	2024-03-01	購入
ナカライテスク株式会社(Nacalai)	36136-14	バリノマイシン Valinomycin from Streptomyces fulvissimus	2001-95-8	100MG	￥35500	2024-03-01	購入

バリノマイシン 化学特性,用途語,生産方法

外観

白色～ほとんど白色、結晶性粉末～粉末

溶解性

クロロホルムに可溶。水に不溶。有機溶剤に可溶。クロロホルム及びメタノールに溶ける。

解説

バリノマイシン，放線菌から得られる抗生物質の一種で，[ (D-バリン)－(L-乳酸)－(L-バリン)－(D-α-ヒドロキシイソ吉草酸) ]3 という 12個の単位が環状につながっている。抗生物質としてはグラム陽性菌に有効である。高等生物に作用させると細胞膜やミトコンドリア膜のカリウム透過性を選択的に高めるので，イオン輸送などにおける研究手段としてしばしば用いられる。バリノマイシンの輪が膜に入り込んでチャンネルを形成し，そこを，大きさの合致するカリウムイオンが通り抜けるものと考えられる。

用途

生体膜研究用、生理作用研究用。

化学的特性

white crystalline powder

使用

Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.

定義

ChEBI: A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in severa Streptomyces strains.

一般的な説明

Shiny crystalline solid. Used as an insecticide and nematocide. Not registered as a pesticide in the U.S.

反応プロフィール

VALINOMYCIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

健康ハザード

VALINOMYCIN is highly toxic orally.

火災危険

When heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides.

生物活性

Selective K + ionophore (K 0.5 values are 48, 73, 75, 93 and 246 mM for K + , Rb + , Cs + , Na + and Li + respectively) that transports K + across biological and artificial lipid membranes. Inhibits Ca 2+ -ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro .

純化方法

Recrystallise valinomycin from dibutyl ether or Et2O. It is dimorphic: modification A crystallises from n-octane, and modification B crystallises from EtOH/H2O. It is soluble in pet ether, CHCl3, AcOH, BuOAc and Me2CO. [Smith et al. J Am Chem Soc 97 7242 1975, UV, IR and NMR see Brocknmann & Schmidt-Kastner Chem Ber 88 57 1955, Beilstein 27 I 9728. 17 IV 9728.]

バリノマイシン 上流と下流の製品情報

原材料

準備製品

バリノマイシン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	1057@dideu.com	China	3487	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9271	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29067	58

2001-95-8(バリノマイシン)キーワード:

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• 2001-95-8
• 1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,
• 14,17,20,23,26,29,32,35-dodecone,12,24,36-trimetyl-3,6,9,15,18,21,27,30,33-non
• akis(1-methylethyl)-[qr]
• aleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l
• antibioticn-329b
• cyclic(d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisov
• nsc122023
• nsc122023[qr]
• valinomicin[qr]
• ValinoMycin, froM StreptoMyces fulvissiMus
• -valyl)[qr]
• VALINOMYCIN
• VALINOMYCIN, STREPTOMYCES FULVISSIMUS
• POTASSIUM IONOPHORE I
• CYCLO[-L-VAL-D-HYLVA-D-VAL-L-LAC-]3
• CYCLO(LAC-VAL-D-HIV-D-VAL-LAC-VAL-D-HIV-D-VAL-)
• Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
• VALINOMYCIN >94% PURITY
• VALINOMYCIN READY MADE SOLUTION
• VALINOMYCIN 99%
• Valinomycin,90%
• Valinomycin,96%
• Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
• VALINOMYCINRESEARCH GRADE
• Potassium ionophore I,Valinomycin
• Valinomycin,Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
• 1Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α- hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
• 3,6,9,15,18,21,27,30,33-Nonaisopropyl-12,24,36-triMethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone
• VALINOMYCIN,CRYSTAL
• Valinomycin, ≥98%(TLC),≥95%(HPLC),solid
• バリノマイシン
• カリウムイオノフォアI
• (2R,5R,8S,11S,14R,17R,20S,23S,26R,29R,32S,35S)-2,5,11,14,17,23,26,29,35-ノナイソプロピル-8,20,32-トリメチル-1,7,13,19,25,31-ヘキサオキサ-4,10,16,22,28,34-ヘキサアザシクロヘキサトリアコンタン-3,6,9,12,15,18,21,24,27,30,33,36-ドデカオン
• (3S,6S,9R,12R,15S,18S,21R,24R,27S,30S,33R,36R)-6,18,30-トリメチル-3,9,12,15,21,24,27,33,36-ノナキス(プロパン-2-イル)-1,7,13,19,25,31-ヘキサオキサ-4,10,16,22,28,34-ヘキサアザシクロヘキサトリアコンタン-2,5,8,11,14,17,20,23,26,29,32,35-ドデカオン
• シクロ(D-Hyiv-D-Val-L-Lac-L-Val-D-Hyiv-D-Val-L-Lac-L-Val-D-Hyiv-D-Val-L-Lac-L-Val-)