EC330

2016795-77-8

CAS番号.: 2016795-77-8

化学名:

别名:

英語名:: EC330

英語别名:: EC330;EC-330; EC 330;EC-330,EC 330,EC330,inhibit,Inhibitor;Estra-4,9-dien-3-one, 11-(4-cyclopropylphenyl)-17-(1,1-difluoro-2-propyn-1-yl)-17-hydroxy-, (11β,17β)-;(8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

CBNumber:: CB43171691

化学式:: C30H32F2O2

分子量:: 462.57

MOL File:: 2016795-77-8.mol

物理性質

安全性情報

用途語

生産企業 45

EC330 物理性質

沸点 :: 623.4±55.0 °C(Predicted)

比重(密度) :: 1.26±0.1 g/cm3(Predicted)

貯蔵温度 :: Store at -20°C

溶解性:: DMSO : 20 mg/mL (43.24 mM)

酸解離定数(Pka):: 12.90±0.60(Predicted)

安全性情報

HSコード	2914409000

EC330 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

EC330 化学特性,用途語,生産方法

説明

EC330 is used as potential LIF inhibitors. The remaining EC330-like inhibitors include EC357, and EC363. They were designed based on the structure–activity relationship (SAR) studies on human breast cancer MCF7 cells with LIF overexpression. The SAR established through this screening includes following criteria: (i) the steroidal skeleton of the molecule is an antiprogestin, (ii) the molecule has the specific 17α-difluoro acetylenic moiety, and (iii) nonpolar substituents at position 11 are preferred over polar substituents. EC330, EC357, and EC363 have all these features. EC330 inhibits the LIF/LIF-R signaling and blocks the promoting effects of LIF on growth and migration of cancer cells.[1].

EC330 上流と下流の製品情報

原材料

準備製品

EC330 生産企業

Global( 45)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Shanghai Gubang New Materail Technology Co. LTD	21-51317962 +8618721305404	16728589@qq.com	CHINA	272	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4604	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55

2016795-77-8
EC330
Estra-4,9-dien-3-one, 11-(4-cyclopropylphenyl)-17-(1,1-difluoro-2-propyn-1-yl)-17-hydroxy-, (11β,17β)-
EC-330; EC 330
EC-330,EC 330,EC330,inhibit,Inhibitor
(8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one