EC330

2016795-77-8

CAS-Nr.: 2016795-77-8

Englisch Name:: EC330

Synonyma:: EC330;EC-330; EC 330;EC-330,EC 330,EC330,inhibit,Inhibitor;Estra-4,9-dien-3-one, 11-(4-cyclopropylphenyl)-17-(1,1-difluoro-2-propyn-1-yl)-17-hydroxy-, (11β,17β)-;(8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

CBNumber:: CB43171691

Summenformel:: C30H32F2O2

Molgewicht:: 462.57

MOL-Datei:: 2016795-77-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 45

EC330 Eigenschaften

Siedepunkt:: 623.4±55.0 °C(Predicted)

Dichte: 1.26±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMSO : 20 mg/mL (43.24 mM)

pka: 12.90±0.60(Predicted)

Sicherheit

HS Code	2914409000

EC330 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

EC330 is used as potential LIF inhibitors. The remaining EC330-like inhibitors include EC357, and EC363. They were designed based on the structure–activity relationship (SAR) studies on human breast cancer MCF7 cells with LIF overexpression. The SAR established through this screening includes following criteria: (i) the steroidal skeleton of the molecule is an antiprogestin, (ii) the molecule has the specific 17α-difluoro acetylenic moiety, and (iii) nonpolar substituents at position 11 are preferred over polar substituents. EC330, EC357, and EC363 have all these features. EC330 inhibits the LIF/LIF-R signaling and blocks the promoting effects of LIF on growth and migration of cancer cells.[1].

EC330 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

EC330 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 45)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Shanghai Gubang New Materail Technology Co. LTD	21-51317962 +8618721305404	16728589@qq.com	CHINA	272	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4604	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55

EC330
Estra-4,9-dien-3-one, 11-(4-cyclopropylphenyl)-17-(1,1-difluoro-2-propyn-1-yl)-17-hydroxy-, (11β,17β)-
EC-330; EC 330
EC-330,EC 330,EC330,inhibit,Inhibitor
(8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
2016795-77-8
C30H32F2O2