3-クロロ-4-(2-ピリジルメトキシ)アニリン
3-クロロ-4-(2-ピリジルメトキシ)アニリン 物理性質
- 融点 :
- 91.0 to 95.0 °C
- 沸点 :
- 402.5±35.0 °C(Predicted)
- 比重(密度) :
- 1.292±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,Room temperature
- 外見 :
- powder to crystal
- 酸解離定数(Pka):
- 3.88±0.10(Predicted)
- 色:
- White to Light yellow to Light orange
3-クロロ-4-(2-ピリジルメトキシ)アニリン 価格
もっと(11)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQE-1801 |
3-クロロ-4-(ピリジン-2-イルメトキシ)アニリン
3-Chloro-4-(pyridin-2-ylmethoxy)aniline |
524955-09-7 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQE-1801 |
3-クロロ-4-(ピリジン-2-イルメトキシ)アニリン
3-Chloro-4-(pyridin-2-ylmethoxy)aniline |
524955-09-7 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
東京化成工業
|
C3150 |
3-クロロ-4-(2-ピリジルメトキシ)アニリン >98.0%(GC)(T)
3-Chloro-4-(2-pyridylmethoxy)aniline
>98.0%(GC)(T) |
524955-09-7 |
1g |
￥6200 |
2024-03-01 |
購入 |
|
東京化成工業
|
C3150 |
3-クロロ-4-(2-ピリジルメトキシ)アニリン >98.0%(GC)(T)
3-Chloro-4-(2-pyridylmethoxy)aniline
>98.0%(GC)(T) |
524955-09-7 |
5g |
￥20300 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQE-1801 |
3-クロロ-4-(ピリジン-2-イルメトキシ)アニリン
3-Chloro-4-(pyridin-2-ylmethoxy)aniline |
524955-09-7 |
25g |
￥40000 |
2024-03-01 |
購入 |
3-クロロ-4-(2-ピリジルメトキシ)アニリン 化学特性,用途語,生産方法
外観
白色～うすい黄色～うすい黄赤色粉末～結晶
使用
3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.
合成
3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL).
The mixture was stirred at 60° C. overnight.
Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate.
The organic phase was separated, washed with saturated brine and dried.
The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained.
1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).
3-クロロ-4-(2-ピリジルメトキシ)アニリン 上流と下流の製品情報
原材料
準備製品
3-クロロ-4-(2-ピリジルメトキシ)アニリン 生産企業
Global( 253)Suppliers
3-クロロ-4-(2-ピリジルメトキシ)アニリン スペクトルデータ(1HNMR)
524955-09-7(3-クロロ-4-(2-ピリジルメトキシ)アニリン)キーワード:
- 524955-09-7
- AKOS B033273
- 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-PHENYLAMINE
- ART-CHEM-BB B033273
- UKRORGSYN-BB BBV-019513
- 3-chloro-4-(2-pyridinylMethoxy)- BenzenaMine
- 3-Chloro-4-[(pyridin-2-yl)Methoxy]benzenaMine [3-Chloro-4-(pyridin-2-ylMethoxy)phenyl]aMine
- BenzenaMine, 3-chloro-4-(2-pyridinylMethoxy)-
- Neratinib Intermediate1
- 3-Chloro-4-(pyridin-2-ylmethoxy)
- 3-Chloro-4-(2-pyridylmethoxy)aniline
- 3-Chloro-4-(pyridine-2-ylmethoxy)aniline
- AKOS B033273(524955-09-7)
- 4-((pyridin-2-yl)methoxy)-3-chlorobenzenamine
- methoxy)aniL
- oro-4-(2-pyridyL
- AKOS B033273 ISO 9001：2015 REACH
- Neratinib Impurity 41
- 524955-09-7 AKOS B033273
- 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE
- 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline
- 3-Chloro-4-(pyridin-2-ylmethoxy)aniline (Neratinib Impurity)
- 3-chloro-4-(pyridin-2-ylmethoxy)aniline
- 3-クロロ-4-(2-ピリジルメトキシ)アニリン
- 3-クロロ-4-(ピリジン-2-イルメトキシ)アニリン