3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド
3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド 物理性質
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- H2O: <2mg/mL
- 外見 :
- 白い固体
- 色:
- オフホワイト
3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド 価格
もっと(10)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-3813 |
Gnf-2 |
778270-11-4 |
250mg |
￥70000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-3813 |
Gnf-2 |
778270-11-4 |
1g |
￥190000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC4399 |
GNF 2 |
778270-11-4 |
50mg |
￥279000 |
2023-06-01 |
購入 |
|
Sigma-Aldrich Japan
|
G9420 |
≥98% (HPLC), solid
GNF-2 ≥98% (HPLC), solid |
778270-11-4 |
5mg |
￥48400 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC4399 |
GNF 2 |
778270-11-4 |
10mg |
￥82000 |
2023-06-01 |
購入 |
3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド 化学特性,用途語,生産方法
説明
GNF-2 is an allosteric inhibitor of Bcr-Abl (IC
50 = 267 nM). It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 μM. It inhibits proliferation of Ba/F3 cells (IC
50 = 138 nM). GNF-2 (10 μM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus,
via inhibition of IBV surface glycoprotein-induced syncytia formation and virus-cell fusion. It inhibits LPS-induced production of nitric oxide (NO) and TNF-α in BV-2 microglia when used at concentrations of 10 and 20 μM. GNF-2 (1 and 10 mg/kg) reduces paw edema and increases the latency to paw withdrawal in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA). It also decreases mechanical and thermal hyperalgesia in a mouse model of diabetic neuropathy induced by streptozotocin (STZ; ).
使用
Bcr-abl Inhibitor is an inhibitor of c-Abl and Bcr-abl activity. It is a COVID19-related research product.
一般的な説明
A cell-permeable and reverisble pyrimidine compound that binds to the c-abl myristoyl binding pocket and acts as an allosteric, non-ATP-competitive inhibitor of cellular Bcr-abl activity and Bcr-abl-dependent cellular functions. Exhibits little inhibitory effect against a panel of 63 kinases even at concentration as high as 10 μM. Exhibits potent and selective antiproliferative activity toward Bcr-abl-expressing cells (IC
50 = 138 nM, 194 nM, 268 nM and 273 nM in Ba/F3.p210, Ba/F3.p
185Y253H, SUP-B15 and Ba/F3.p
210E255V, and K562, respectively). Brij-35 is reported to mask the inhibitory effect of GNF-2 in cell-free c-abl and Bcr-abl kinase assays.
3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド 上流と下流の製品情報
原材料
準備製品
3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド 生産企業
Global( 130)Suppliers
3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド スペクトルデータ(1HNMR)
778270-11-4(3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド)キーワード:
- 778270-11-4
- 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-2
- GNF-2 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
- GNF 2, >=98%
- 3-(6-(4-(TRIFLUOROMETHOXY)PHENYLAMINO)PYRIMIDIN-4-YL)BENZAMIDE
- Benzamide, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-
- GNF-2
- Bcr-abl Inhibitor
- 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
- Bcr-abl Inhibitor - CAS 778270-11-4 - Calbiochem
- CS-569
- GNF2;GNF 2
- GNF-2 USP/EP/BP
- SARS coronavirus,GNF-2,allosteric,GNF 2,non-ATP competitive inhibitor,Ba/F3.p185Y253H,Bcr-Abl,Ba/F3.p210E255V,SARS-CoV,Ba/F3.p210,bone erosion,Inhibitor,inhibit
- 3-(6-{[4-(トリフルオロメトキシ)フェニル]アミノ}ピリミジン-4-イル)ベンズアミド
- 3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド