リノピルジン

リノピルジン 価格 もっと(4)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01COBQV-3332	リノピルジン Linopirdine	105431-72-9	250mg	￥215000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQV-3332	リノピルジン Linopirdine	105431-72-9	1g	￥540000	2024-03-01	購入
Sigma-Aldrich Japan	L134	≥98% (HPLC) Linopirdine ≥98% (HPLC)	105431-72-9	10mg	￥44200	2024-03-01	購入
Sigma-Aldrich Japan	L134	≥98% (HPLC) Linopirdine ≥98% (HPLC)	105431-72-9	50mg	￥174000	2024-03-01	購入

リノピルジン 化学特性,用途語,生産方法

効能

認知症治療薬

説明

Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; K_v7.2/7.3; KCNQ2/3) K⁺ current with an IC₅₀ value of 2.4 μM. Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca²⁺ influx and increased neurotransmitter release. Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory. Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC₅₀ = 115 μM in HEK293 cells voltage clamped at -60 mV).

使用

Alzheimer’s disease treatment (cognition enhancer).

生物活性

Blocker of KCNQ voltage-gated potassium channels; blocks KCNQ2+3/M-currents (IC 50 = 4-7 μ M) and KCNQ1 homomeric channels (IC 50 = 8.9 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .

リノピルジン 上流と下流の製品情報

原材料

準備製品

リノピルジン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Shanghai Hanhong Scientific Co.,Ltd.	021-021-64543801 13764082696	2355241799@qq.com	China	42982	64
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60

105431-72-9(リノピルジン)キーワード:

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• 105431-72-9
• LINOPIRDINE DIHYDROCHLORIDE
• 1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE
• LINOPIRDINE (DUP996)
• Linopirdine2HCl
• DuP 996, 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one
• 1-Phenyl-3,3-bis(4-pyridinylmethyl)-2,3-dihydro-1H-indole-2-one
• 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one
• linopiridine
• 1,3-Dihydro-1-Phenyl-3,3-Bis(4-Pyridinylmethyl)-2H-Indol-2-One(WXC03502)
• 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride
• 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-
• 1-Phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
• Kv7,enhancing,inhibit,DuP-996,TRP Channel,Inhibitor,Transient receptor potential channels,KcsA,current,acetylcholine,Channels,Linopirdine,DuP996,orally,Potassium Channel,TRPV1,KCNQ,M-type,cognition
• 1,3-ジヒドロ-1-フェニル-3,3-ビス[(4-ピリジニル)メチル]-2H-インドール-2-オン
• 1-フェニル-3,3-ビス(4-ピリジニルメチル)-1H-インドール-2(3H)-オン
• 1-フェニル-3,3-ビス(4-ピリジニルメチル)-1,3-ジヒドロ-2H-インドール-2-オン
• 1-フェニル-3,3-ビス(4-ピリジニルメチル)-2,3-ジヒドロ-1H-インドール-2-オン
• 1,3-ジヒドロ-1-フェニル-3,3-ビス(4-ピリジルメチル)-2H-インドール-2-オン
• リノピルジン
• 1-フェニル-3,3-ビス[(4-ピリジル)メチル]-1H-インドール-2(3H)-オン
• リノプリジン
• 1-フェニル-3,3-ビス(4-ピリジルメチル)-1H-インドール-2(3H)-オン
• 1-フェニル-3,3-ビス[(ピリジン-4-イル)メチル]-2,3-ジヒドロ-1H-インドール-2-オン