(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide 物理性質
- 比重(密度) :
- 1.24±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMF:1.0(Max Conc. mg/mL);3.7(Max Conc. mM)
DMSO:1.0(Max Conc. mg/mL);3.7(Max Conc. mM)
- 外見 :
- 粉
- 酸解離定数(Pka):
- 8.27±0.35(Predicted)
- 色:
- 白からベージュ
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
SML2017 |
≥98% (HPLC)
Compound C108 ≥98% (HPLC) |
15533-09-2 |
5mg |
￥16100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML2017 |
≥98% (HPLC)
Compound C108 ≥98% (HPLC) |
15533-09-2 |
25mg |
￥64300 |
2024-03-01 |
購入 |
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide 化学特性,用途語,生産方法
使用
2-Hydroxy-benzoic Acid [1-(2-Hydroxyphenyl)ethylidene]hydrazide is a GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) inhibitor. G3BP2 is involved with breast tumor initiation.
Biochem/physiol Actions
C108 is a small molecule that exhibits cancer-selective cytotoxicity (Viability = 100%/MCF-10A vs. 50%/BT-474, 67%/4T1, 70%/MDA-MB-231 & MDA-MB-453 post 48 h 1 μM C108 treatment) and synergizes with low dose paclitaxel in reducing ALDH-positive tumor-initiating cells (TIC poulation = 56.6%/control, 60.6%/0.1 μM paclitaxel alone, 47.4%/1 μM C108 alone, 7.3%/combined treatment for 24 h in BT474 breast cancer cultures) by targeting stress granule-associated protein G3BP2 (GAP SH3 domain-binding protein 2). Likewise, C108 pretreatment prior to xenografting greatly reduces BT-474 tumor-initiating frequency (from 1/175 to 1/1103 by limiting dilution xenograft assays) in mice in vivo. G3BP2 is reported to bind and stabilize SART3 mRNA, thereby indirectly regulating the core pluripotency transcription factors Oct-4 and Nanog critically involved in ESC self-renewal and breast tumor initiation.
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide 上流と下流の製品情報
原材料
準備製品
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide 生産企業
Global( 19)Suppliers
- 15533-09-2
- (E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
- Compound C108
- Compound C108 >=98% (HPLC)
- Compound C108,Compound C-108
- Benzoic acid, 2-hydroxy-, 2-[1-(2-hydroxyphenyl)ethylidene]hydrazide
- 2-hydroxy-benzoicacid,2-[1-(2-hydroxyphenyl)ethylidene]hydrazide