ブナフチン 化学特性,用途語,生産方法
効能
抗不整脈薬, カリウムチャネル遮断薬
Originator
Bunaftine,Malesci
Manufacturing Process
Into a solution containing α-naphthoic acid chloride in benzene with agitation
and cooling for 0.5 h a benzene solution of N,N-diethylamine-ethyl-N'-(nbutyl)
amine is dropped. As the dropping is ended, the solution is kept under
agitation in a water bath for 3 h.
After cooling the benzene solution is extracted with 10% hydrochloric acid;
then the aqueous solution is saturated with potassium carbonate. The
separated oil is extracted with ether and, after drying on sodium sulfate, the
solvent is removed and the residue is vacuum distilled. So the N-(2-
diethylamino-ethyl)-N-(n-butyl)-1-naphthalenecarboxamide, boiling point
178°C/0.1 mm/Hg.
Therapeutic Function
Antiarrhythmic
ブナフチン 上流と下流の製品情報
原材料
準備製品