エチホキシン
エチホキシン 物理性質
- 融点 :
- 90-92℃
- 沸点 :
- 421.2±55.0 °C(Predicted)
- 比重(密度) :
- 1.1716 (rough estimate)
- 蒸気圧:
- 0-1Pa at 20-25℃
- 屈折率 :
- 1.5800 (estimate)
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- DMSO:60.0(Max Conc. mg/mL);199.47(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);99.74(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.33(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);66.49(Max Conc. mM)
- 外見 :
- Solid:particulate/powder
- 酸解離定数(Pka):
- 4.89±0.40(Predicted)
- LogP:
- 4.09-4.52 at 21-25℃ and pH7
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY15999 |
Etifoxine |
21715-46-8 |
5mg |
￥24100 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY15999 |
Etifoxine |
21715-46-8 |
10mg |
￥36100 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY15999 |
Etifoxine |
21715-46-8 |
25mg |
￥82900 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY15999 |
Etifoxine |
21715-46-8 |
50mg |
￥152900 |
2024-03-01 |
購入 |
エチホキシン 化学特性,用途語,生産方法
効能
抗不安薬, トランキライザー
Originator
Circupon,Troponwerke,W. Germany
Manufacturing Process
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
Therapeutic Function
Tranquilizer
エチホキシン 上流と下流の製品情報
原材料
準備製品
エチホキシン 生産企業
Global( 70)Suppliers
21715-46-8(エチホキシン)キーワード:
- 21715-46-8
- etafenoxine
- 36-801
- 6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
- Etifoxin
- HOE-36801
- HOE-36-801
- 2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine
- Etifoxine
- 4H-3,1-Benzoxazin-2-amine, 6-chloro-N-ethyl-4-methyl-4-phenyl-
- Etifoxine (HOE36801)
- 6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine
- エチホキシン
- 6-クロロ-N-エチル-4-メチル-4-フェニル-4H-3,1-ベンゾオキサジン-2-アミン
- 6-クロロ-2-(エチルアミノ)-4-メチル-4-フェニル-4H-3,1-ベンゾオキサジン
- 6-クロロ-2-エチルアミノ-4-メチル-4-フェニル-4H-3,1-ベンゾオキサジン