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CP-547632

化学構造式
252003-65-9
CAS番号.
252003-65-9
化学名:
别名:
英語名:
CP-547632
英語别名:
CS-1957;CP-547632;CP-547632(CP 547632);CP-547632 (PAN-90806);3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox;3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami;3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide;3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide;3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide;3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide
CBNumber:
CB82473822
化学式:
C20H24BrF2N5O3S
分子量:
532.4
MOL File:
252003-65-9.mol

CP-547632 物理性質

沸点 :
548.6±50.0 °C(Predicted)
比重(密度) :
1.532
貯蔵温度 :
2-8°C
溶解性:
DMSO: 94 mM
外見 :
A solid
酸解離定数(Pka):
12.50±0.70(Predicted)

安全性情報

CP-547632 価格 もっと(1)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01MAS097193
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide 		252003-65-9 250mg ￥2260400 2024-03-01 購入

CP-547632 化学特性,用途語,生産方法

説明

CP 547,632 is an orally bioavailable and potent inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and basic fibroblast growth factor (bFGF) with IC50 values of 11 and 9 nM, respectively, in an enzyme assay. It is selective for VEGFR2 and bFGF over EGFR, PDGF receptor β (PDGFRβ), and related tyrosine kinases. CP 547,632 inhibits VEGFR2 autophosphorylation induced by VEGF in porcine aortic endothelial cells transfected with VEGFR2 (IC50 = 6 nM) and in a xenograft mouse model using NIH3T3/H-Ras cells (EC50 = 590 nM). It decreases angiogenesis induced by VEGF or bFGF and suppresses tumor growth in athymic mice.

CP-547632 上流と下流の製品情報

原材料

準備製品

CP-547632 (hydrochloride)

CP-547632 生産企業

Global( 62)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49391 58
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
Shanghai Likang New Materials Co., Limited 		+86-16631818819 +86-17736933208
 3684455296@qq.com China 9311 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131980 58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd 19975279805
 1900830611@qq.com China 956 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2923 55
Chembest Research Laboratories Limited 021-20908456
sales@BioChemBest.com China 6010 61
China Kouting Group Limited +86 (21) 5811-6473 5811-6475
sales@koutingchina.com China 496 60

  スペクトルデータ(1HNMR)

CP-547632(252003-65-9)1HNMR

252003-65-9()キーワード:

1,1,1,2-テトラフルオロ-2,2-ジブロモエタン ペンタフルオロベンジルブロミド
  • 252003-65-9
  • CP-547632
  • 3-(4-Bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide
  • 4-Isothiazolecarboxamide, 3-((4-bromo-2,6-difluorophenyl)methoxy)-5-((((4-(1-pyrrolidinyl)butyl)amino)carbonyl)amino)-
  • CP-547632(CP 547632)
  • 3-[(4-broMo-2,6-difluorophenyl)Methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]aMino]carbonyl]aMino]-4-isothiazolecarboxaMide
  • 3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxami
  • 3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carbox
  • 3-[(4-Bromo-2,6-difluorobenzyl)oxy]-5-[3-[4-(pyrrolidin-1-yl)butyl]ureido]isothiazole-4-carboxamide
  • CS-1957
  • CP-547632 (PAN-90806)
  • 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide
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