ナプロキセン 化学特性,用途語,生産方法
外観
白色～ほとんど白色, 結晶性粉末～粉末
溶解性
エタノール及びアセトンに溶けやすく、水にほとんど溶けない。
用途
プロピオン酸系化合物です。
シクロオキシゲナーゼ（COX）を阻害し、プ
ロスタグランジン生合成抑制作用を示しま
す。
用途
薬理研究用。
用途
ナプロキセン (naproxen) は、芳香族カルボン酸に分類される有機化合物で、鎮痛、解熱、抗炎症薬として用いられる非ステロイド性抗炎症薬 (NSAIDs) の一種である。光学活性化合物であり、薬物として有効なのは (S)-(+)体 のエナンチオマーである。
効能
鎮痛薬, 抗炎症薬, 解熱薬, シクロオキシゲナーゼ阻害薬
商品名
ナイキサン (田辺三菱製薬)
説明
Naproxen is synthesized from 2-methoxynaphthalene and the (+)-isomer obtained by resolution with cinchonidine
(61). It was introduced in the United States in 1976 and, as a generic drug, has consistently been among the more
popular NSAIDs. It is marketed as the S-(+)-enantiomer, but interestingly, the sodium salt of the (–)-isomer also is on
the market as Anaprox. As an inhibitor of prostaglandin biosynthesis, it is 12 times more potent than aspirin, 10 times
more potent than phenylbutazone, three to four times more potent than ibuprofen, and four times times more potent
than fenoprofen, but it is approximately 300 times less potent than indomethacin.
化学的特性
white to light yellow crystal powde
使用
Being analogous to other drugs of this series, naproxene exhibits analgesic, fever-reducing, and long-lasting anti-inflammatory action. It causes reduction and removal of
painful symptoms including joint pain, stiffness, and swelling in the joints. It is used in
the same indications as ibuprofen.
定義
ChEBI: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such a
osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
適応症
Naproxen (Naprosyn) also has pharmacological
properties and clinical uses similar to those of ibuprofen.
It exhibits approximately equal selectivity for
COX-1 and COX-2 and is better tolerated than certain
NSAIDs, such as indomethacin. Adverse reactions related
to the GI tract occur in about 14% of all patients,
and severe GI bleeding has been reported. CNS complaints
(headache, dizziness, drowsiness), dermatological
effects (pruritus, skin eruptions, echinoses), tinnitus,
edema, and dyspnea also occur.
一般的な説明
Naproxen (Naprosyn, Anaprox), marketed as the (S)-enantiomer,is well absorbed after oral administration, givingpeak plasma levels in 2 to 4 hours and a half-life of 13 hours.Naproxen is highly protein bound and displaces most protein-bound drugs. It is recommended for use in RA, OA, acute gouty inflammation, and in primary dysmenorrhea. Itshows good analgesic activity (i.e., 400 mg is comparable to75–150 mg of oral meperidine and superior to 65 mg ofpropoxyphene and 325 mg of aspirin plus 30 mg of codeine).It is also available OTC as 200-mg tablets (Aleve).
薬物動態学
Naproxen is almost completely absorbed following oral administration. Peak plasma levels are achieved within 2 to 4
hours following administration. Like most of the acidic NSAIDs (pKa = 4.2), it is highly bound (99.6%) to plasma
proteins. Approximately 70% of an administered dose is eliminated as either unchanged drug (60%) or as conjugates
of unchanged drug (10%). The remainder is converted to the 6-O-desmethyl metabolite by both CYP3A4 and CYP1A2
and, further, to the glucuronide conjugate of the demethylated metabolite. The 6-O-desmethyl metabolite lacks
anti-inflammatory activity. Like most of the arylalkanoic acids, the most common side effect associated with the use
of naproxen is irritation to the GI tract. The most common other adverse reactions are associated with CNS
disturbances (e.g., nausea and dizziness).
臨床応用
Naproxen is indicated for the treatment of rheumatoid arthritis, osteoarthritis, juvenile arthritis, ankylosing
spondylitis, tendinitis, bursitis, acute gout, and primary dysmenorrhea and for the relief of mild to moderate pain.
副作用
Common side effects of Naproxen may include indigestion, heartburn, stomach pain, nausea, headache, dizziness, drowsiness, bruising, itching, rash, swelling, or ringing in the ears. Seek immediate medical attention if you have any of the following serious drug reactions. For example: shortness of breath, swelling or rapid weight gain, rash, signs of stomach bleeding (bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds), liver problems (nausea, upper stomach pain, itching, feeling tired, flu-like symptoms, loss of appetite, dark urine, clay-coloured stools, jaundice), kidney problems (little or no urination, pain or difficulty in urinating, swelling of the feet or ankles, feeling tired or shortness of breath), low red blood cells (anaemia), etc. In addition, in rare cases, a severe allergic reaction to naproxen may occur. You may also suffer from stomach ulcers and other adverse reactions when taking it for a long time.
ナプロキセン 上流と下流の製品情報
原材料
準備製品