クレソキシムメチル 化学特性,用途語,生産方法
外観
白色～うすい褐色, 結晶性粉末～粉末
溶解性
アセトンに溶け、水にほとんど溶けない。
用途
農薬(殺菌剤)
用途
クレソキシムメチル試験用標準品。
農薬用途
殺菌剤
説明
Kresoxim-methyl is a strobilurin fungicide. It inhibits conidial germination of
V. inaequalis isolates from apple orchards (EC
50s = 0.00033-0.0078 mg/L). Kresoxim-methyl also inhibits mycelial growth (EC
50 = 0.240 mg/L) and is fungicidal against
Saprolegnia (MIC = 1 mg/L). It increases intracellular calcium levels and disrupts the mitochondrial membrane potential in mouse cortical cultures in a concentration-dependent manner. Kresoxim-methyl is toxic to goldfish (
C. auratus; LC
50 = 0.807 mg/L).
使用
Kresoxim-methyl is used for the control of several diseases (scab,
mildews, blast, sheath blight and others) on a range of crops including
apples, pears, vines, sugar beet and cereals.
定義
ChEBI: A carboxylic ester that is the methyl ester of (2E)-(methoxyimino){2-[(2-methylphenoxy)methyl]phenyl}acetic acid. A fungicide for the control of scab on apples and pears and other fungal diseases on a wide range of crops.
危険性
Moderately toxic by skin contact. Low tox-icity by ingestion and inhalation.
安全性プロファイル
Moderately toxic by
skin contact. Low toxicity by ingestion and
inhalation. Questionable carcinogen with
experimental data reported. When heated to
decomposition it emits toxic vapors of NOx.
代謝経路
By hepatocyte suspensions prepared from goats, pigs,
hens, and rats that have been cryopreserved and
thawed, BAS 490 F is metabolized via the same
pathways as observed using fresh rat hepatocytes.
The rate of hydrolysis of 14C-BAS 490 F leading to a
carboxylic acid derivative seems to be constant
between the cryopreserved and fresh hepatocytes
except for goats. The oxidation reaction at the methyl
group of the phenoxy ring, leading to the
hydroxymethyl analog of the carboxylic acid of BAS
490 F, significantly decreases after cryopreservation,
whereas the formation of (E)-2-methoxyimino-2[2-(4-
hydroxy-2-methylphenyloxymethyl)phenyl] acetic acid
by hydroxylation at the 4-position of the phenoxy ring
remains at a constant rate. In pig hepatocytes, the two
hydroxylated metabolites of the phenoxy ring, carboxy
BAS 409 F and (E)-2-methoxyimino-2-o-
hydroxymethylphenyl acetic acid, are formed to a
lesser extent after cryopreservation.
代謝
Kresoxim-methyl is rapidly metabolized in mammalian
systems to the virtually inactive carboxylic acid, accounting
for its low toxicity and high level of selectivity. Atharvest
residues in cereals and top fruit are <0.05 mg/kg
and <1 mg/kg in grapes and vegetables. The soil DT
50 =
<3 days, and the Koc is 219 to 372. For the main metabolite,
the Koc is 17 to 24. Hydrolytic stability tests indicate
a DT
50 of 34 days at pH 7 but only 7 h at pH 9.
クレソキシムメチル 上流と下流の製品情報
原材料
準備製品