二酢酸カルシウム 化学特性,用途語,生産方法
定義
本品は、酢酸(*)のカルシウム塩であり、次の化学式で表される。
参照表示名称：酢酸
解説
Ca(CH3COO)2(158.18)．酢酸カルシウムは，酢酸と水酸化カルシウムまたは炭酸カルシウムとを反応させ，濾過したのち濃縮し，冷却すると二水和物(無色の結晶)が得られる．二水和物を熱すると84 ℃ で一水和物(無色の結晶)が，また100 ℃ で無水物(白色の粉末)が得られる．無水物は吸湿性があり，160 ℃ 以上で乾留するとアセトンとCaCO3とに分解する(アセトンの実験室的製法)．二水和物を空気中に放置すると徐々に結晶水の一部を失って一水和物となる．いずれも水に可溶，エタノールに難溶．アセトン，酢酸，酢酸塩の製造，染色，皮なめし，食品安定化剤，プラスチックの安定剤，医薬品などに用いられる．[CAS 62-54-4:Ca(CH3COO)2][CAS 5473-26-0:Ca(CH3COO)2･H2O] 森北出版「化学辞典（第2版）
用途
医薬品原料、アセトン、酢酸等の製造原料
製造法
二酢酸カルシウムは，酢酸とカルシウムのつくる塩。化学式Ca(CH3CO2)2。分子量158.17。水酸化カルシウムに酢酸を反応させて、濾過(ろか)、冷却すると二水和物が得られ、これを熱すると84℃で一水和物が得られる。これらを脱水して酢酸カルシウムとする。酢酸カルシウム（無水和物）は、白色粉末、20℃の水100グラムに34.73グラム溶ける。160℃に加熱すると炭酸カルシウムと、アセトンに分解する。［佐藤武雄］
化粧品の成分用途
香料
効能
高リン血症治療薬
説明
Calcium acetate is a chemical compound which is calcium salt of acetic acid. It has the formula Ca(C
2H
3O
2)
2. Its standard name is calcium acetate, while calcium ethanoate is the systematic name. An older name is acetate of lime. The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH
3COO)
2?H
2O) is the common form.
化学的特性
Calcium acetate occurs as a white or almost white, odorless or
almost odorless, hygroscopic powder.
使用
Calcium Acetate is the calcium salt of acetic acid which functions
as a sequestrant and mold control agent. it contains approximately
25% calcium. it is a white odorless powder which is readily soluble
in water with a solubility of approximately 37 g in 100 g water at
0°c. its solubility decreases with increasing temperature, with a sol-
ubility of approximately 29 g in 100 g of water at 100°c.
製造方法
Produced by calcium hydroxide neutralization of acetic acid.
調製方法
Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as lime stone or marble) in vinegar:
CaCO
3 + 2CH
3COOH → Ca(CH
3COO)
2 + H2O + CO
2 Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.
定義
ChEBI: The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is
excreted in the faeces.
一般的な説明
Calcium Acetate belongs to the group of calcium salts, widely used as phosphorus binders in patients with chronic renal failure.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
応用例（製薬）
Calcium acetate is used as a preservative in oral and topical
formulations.
Therapeutically, parenteral calcium acetate acts as a source of
calcium ions for hypocalcemia or electrolyte balance. Oral
calcium acetate is used as a complexing agent for hyperphosphatemia
in dialysis patients. Calcium acetate is also used in the
food industry as a stabilizer, buffer and sequestrant.
安全性プロファイル
Poison by intravenous
and intraperitoneal routes. Mutation data
reported. See also CALCIUM
COMPOUNDS. When heated to
decomposition it emits acrid smoke and
fumes.
安全性
Calcium acetate is used in oral and topical formulations. The pure
form of calcium acetate is toxic by IP and IV routes.
LD
50 (mouse, IP): 0.075 g/kg
LD
50 (mouse, IV): 0.052 g/kg
LD
50 (rat, oral): 4.28 g/kg
貯蔵
Calcium acetate is stable although very hygroscopic, and so the
monohydrate is the common form. It decomposes on heating (above
1608℃) to form calcium carbonate and acetone.
Store in well-closed airtight containers.
純化方法
Recrystallise it from water (3mL/g) by partial evaporation in a desiccator. [Beilstein 2 IV 113.]
不和合性
Calcium acetate is incompatible with strong oxidizing agents and
moisture.
規制状況(Regulatory Status)
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral suspensions
and tablets; topical emulsions, lotions, and creams). Included
in nonparenteral medicines (oral tablets) licensed in the UK.
二酢酸カルシウム 上流と下流の製品情報
原材料
準備製品