イソチオシアン酸1-ナフチル 化学特性,用途語,生産方法
外観
白色～うすい黄色粉末～結晶
溶解性
アセトンに溶け、水にほとんど溶けない。
説明
1-Napthylisothiocyanate is a toxic chemical that has been used
to create experimental cholestasis in rodents. Laboratory
studies have also shown that 1-napthylisothiocyanate can act as
a chemoprotectant in rodents challenged with a tumorinducing
agent such as phorbol-12 myristate 13-acetate.
化学的特性
white crystalline powder
使用
1-Naphthyl isothiocyanate is a tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function.
一般的な説明
Odorless white needles or powder. Tasteless.
空気と水の反応
1-Naphthyl isothiocyanate is moisture sensitive. . Undergoes slow hydrolysis. Insoluble in water.
反応プロフィール
Isocyanates and thioisocyanates, such as 1-Naphthyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
火災危険
Flash point data for 1-Naphthyl isothiocyanate is not available, but 1-Naphthyl isothiocyanate is probably combustible.
環境運命予測
Naphthylisothiocyanate is moisture sensitive and insoluble in
water. The hydrolysis rate is slow.
純化方法
Crystallise the isothiocyanate from hexane (1g in 9 mL). It forms white needles and is soluble in most organic solvents but is insoluble in H2O. It is absorbed through the skin and may cause dermatitis. [Cymmerman-Craig et al. Org Synth Coll Vol IV 700 1963, Beilstein 12 H 1244, 12 III 2948.]
イソチオシアン酸1-ナフチル 上流と下流の製品情報
原材料
準備製品