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FK-506-13C-d2

化学構造式
1356841-89-8
CAS番号.
1356841-89-8
化学名:
别名:
英語名:
FK-506-13C-d2
英語别名:
TACROLIMUS (13C, 99%;Tacrolimus-13C;Tacrolimus-13C,D2 solution;Tacrolimus-13C, D2 (major);Methadone Hydrochloride Impurity 9;D2, 98%) 100 UG/ML IN ACETONITRILE;FK-506-13C,D2 (Major) (Tacrolimus) (>FK-506-13C,D2 (Major) (Tacrolimus)(>85%);Fujimycin-13C,D2 Tacrolimus-13C D2 FK-506-13C,D2;Tacrolimus 13CD2Q: What is Tacrolimus 13CD2 Q: What is the CAS Number of Tacrolimus 13CD2 Q: What is the storage condition of Tacrolimus 13CD2 Q: What are the applications of Tacrolimus 13CD2
CBNumber:
CB93141783
化学式:
C44H67D2NO12
分子量:
807.039483556
MOL File:
1356841-89-8.mol

FK-506-13C-d2 物理性質

貯蔵温度 :
-70°C
溶解性:
Chloroform: Slightly Soluble,Methanol: Slightly Soluble
外見 :
A solid
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
RIDADR  UN 1648 3 / PGII
絵表示（GHS） GHS hazard pictograms
注意喚起語
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P301+P310 飲み込んだ場合：直ちに医師に連絡すること。
P321 特別な処置が必要である（このラベルの．．． を見よ）。
P330 口をすすぐこと。
P405 施錠して保管すること。
P501 内容物/容器を．．．に廃棄すること。

FK-506-13C-d2 価格 もっと(5)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCF370002
FK-506-13C,D2 (Major) (Tacrolimus)(>85%) 		1356841-89-8 0.5mg ￥180600 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCF370002
FK-506-13C,D2 (Major) (Tacrolimus)(>85%) 		1356841-89-8 2.5mg ￥802800 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCF370002
FK-506-13C,D2 (Major) (Tacrolimus)(>85%) 		1356841-89-8 5mg ￥687500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCF370002
FK-506-13C,D2 (Major) (Tacrolimus)(>85%) 		1356841-89-8 1mg ￥162500 2018-12-26 購入
Sigma-Aldrich Japan T-066 100?μg/mL in acetonitrile, certified reference material, ampule of 1?mL
Tacrolimus-13C,D2 solution 100?μg/mL in acetonitrile, certified reference material, ampule of 1?mL		 1356841-89-8 1ml ￥179700 2018-12-25 購入

FK-506-13C-d2 化学特性,用途語,生産方法

説明

FK-506-13C-d2 contains two deuterium atoms located on the carbon-13 bond. It is intended for use as an internal standard for the quantification of FK-506 by GC- or LC-MS. FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin. Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation. The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+ release via the ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors. In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3 receptors which can be disrupted by FK-506, thereby rendering the receptors “leaky” to Ca2+.

一般的な説明

This stable-labeled internal standard is suited for quantitation of tacrolimus by LC/MS or GC/MS for clinical toxicology, therapeutic drug monitoring, or isotope dilution methods. Tacrolimus, also known as FK-506 or fujimycin, is an immunosuppressive drug marketed as Prograf, Advagraf, and Protopic usually used to prevent rejection of organ transplants and treatment of eczema. Use of a stable-labeled analog of tacrolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.

FK-506-13C-d2 上流と下流の製品情報

原材料

準備製品

FK-506-13C-d2 生産企業

Global( 25)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
SIMSON PHARMA LIMITED 		+91-8291074273
k.das@simsonpharma.com India 228 58
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656
 greensnown@163.com China 9911 50
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80
Artis Biotech Co. Ltd. 19138486554 18582380095
 sales@artisbio.com China 2804 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11289 58
Cato Research Chemicals Inc. 020-81215950 4000-868-328
 customer@uwalab.com United States 10413 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050
 info@synzest.com China 9287 58
Energy Chemical 021-58432009 400-005-6266
 marketing1@energy-chemical.com China 44843 58
QUALITY CONTROL SOLUTIONS LTD. 13670046396
 ORDERS@QCSRM.COM China 18820 58
Nanjing Shizhou Biology Technology Co.,Ltd 18351873721
 helen.zhang@synzest.com China 8298 58
  • 1356841-89-8
  • (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-13C-d2)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone
  • Tacrolimus-13C
  • Tacrolimus-13C,D2 solution
  • TACROLIMUS (13C, 99%
  • FK-506-13C,D2 (Major) (Tacrolimus) (>
  • (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl-3-13C-d2)-
  • FK-506-13C,D2 (Major) (Tacrolimus)(>85%)
  • D2, 98%) 100 UG/ML IN ACETONITRILE
  • Tacrolimus 13CD2Q: What is Tacrolimus 13CD2 Q: What is the CAS Number of Tacrolimus 13CD2 Q: What is the storage condition of Tacrolimus 13CD2 Q: What are the applications of Tacrolimus 13CD2
  • Fujimycin-13C,D2 Tacrolimus-13C D2 FK-506-13C,D2
  • Methadone Hydrochloride Impurity 9
  • Tacrolimus-13C, D2 (major)
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