5-HYDROXYINDOLE-3-ACETIC ACID
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5-HYDROXYINDOLE-3-ACETIC ACID 속성
- 녹는점
- 161-164 °C (dec.) (lit.)
- 끓는 점
- 326.92°C (rough estimate)
- 밀도
- 1.2722 (rough estimate)
- 굴절률
- 1.5310 (estimate)
- 저장 조건
- -20°C
- 용해도
- 에탄올(50mg/ml)에 용해됩니다.
- 산도 계수 (pKa)
- 4.54±0.30(Predicted)
- 물리적 상태
- 수정 같은
- 색상
- 황백색에서 보라색까지
- 감도
- Light Sensitive
- BRN
- 168797
- 안정성
- 공기 민감성, 빛 민감성
- InChIKey
- DUUGKQCEGZLZNO-UHFFFAOYSA-N
- CAS 데이터베이스
- 54-16-0
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
5-HYDROXYINDOLE-3-ACETIC ACID C화학적 특성, 용도, 생산
개요
5-hydroxy Indole-3-acetic acid (5-HIAA) is the primary metabolite of serotonin (5-HT; ). It is formed when 5-HT is metabolized by monamine oxidase and aldehyde dehydrogenase in the liver. 5-HIAA is excreted in urine and has been used as a biomarker for detection of neuroendocrine tumors and an internal standard for the quantification of serotonin metabolism in rat brain using mass spectrometry. 5-HIAA has also been associated with autism, insomnia, and chronic migraine.화학적 성질
beige crystalline powder용도
5-Hydroxyindole-3-acetic acid is an impurity of chlorpheniramine (C424300), an antihistaminic agent.정의
ChEBI: A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.일반 설명
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).Mechanism of action
The primary product of the metabolism of serotonin. Formed by the oxidative deamination of serotonin by monoamine oxidase, presumably the A isozyme, 5-HIAA is subsequently cleared by an active transport mechanism. Unlike serotonin, 5-HIAA is not a neurotransmitter and thus its formation contributes to the termination of the synaptic actions of serotonin. Inhibition of monoamine oxidase activity enhances and prolongs the actions of serotonin.5-HYDROXYINDOLE-3-ACETIC ACID 준비 용품 및 원자재
원자재
준비 용품
5-HYDROXYINDOLE-3-ACETIC ACID 공급 업체
글로벌( 163)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9341 | 55 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; |
info@afinechem.com | China | 15377 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 |
dj@sgtlifesciences.com | China | 12382 | 58 |
5-HYDROXYINDOLE-3-ACETIC ACID 관련 검색:
인돌-3-아세트산 5-히드록시인돌
5-METHYLINDOLE-3-CARBOXALDEHYDE
ETHYL 2-METHYL-2,3-DIHYDRO-INDOLE-3-CARBOXYLATE
5-Methoxy-3-indolecarboxylic acid
1-Methylindole-2-carboxylic acid
1-INDOLEPROPIONIC ACID
4-Methoxy-1H-indole-2-carboxylic acid
1-Methylindole-3-carboxaldehyde
3-Indolepropionic acid
Methyl indole-5-carboxylate
N-[(tert-Butoxy)carbonyl]-D-tryptophan
5-Bromo-6-chloro-3-indolyl-beta-D-galactoside
5-HYDROXYINDOLE-3-ACETIC ACID
5-hydroxyindole-3-acetic acid*dicyclohexylammoniu,5-HYDROXYINDOLE-3-ACETIC ACID*DICYCLOHEX YLAMMONIUM,5-HYDROXYINDOLE-3-ACETIC ACID DICYCLOHEXYLAMMONIUM SALT
5-Hydroxyindole-3-acetic acid diethylammonium salt
2,3-DIHYDRO-5-HYDROXYINDOLE-3-ACETIC ACID
5-Hydroxyindole-3-Acetic Acid-D2