Clemastine fumarate
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Clemastine fumarate 속성
- 녹는점
- 158-162°C
- 알파
- D21 +16.9° (methanol)
- 끓는 점
- 154°C (rough estimate)
- 밀도
- 1.0247 (rough estimate)
- 굴절률
- 1.5790 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: 가용성 5mg/mL(투명 용액, 가열)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- optical activity
- [α]/D +15 to +25°, c = 1 in methanol
- InChIKey
- PMGQWSIVQFOFOQ-YKVZVUFRSA-N
- CAS 데이터베이스
- 14976-57-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | 3 | ||
|---|---|---|---|
| RTECS 번호 | UY0704600 | ||
| HS 번호 | 2933992600 | ||
| 유해 물질 데이터 | 14976-57-9(Hazardous Substances Data) | ||
| 독성 | LD50 in mice, rats (mg/kg): 730, 3550 orally; 43, 82 i.v. (Weimann) |
Clemastine fumarate MSDS
(2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine but-2-enedioic acid
Clemastine fumarate C화학적 특성, 용도, 생산
화학적 성질
White Solid용도
Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM). It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling. Clemastine fumarate has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.정의
ChEBI: The fumaric acid salt of clemastine. An antihistamine with antimuscarinic and moderate sedative properties, it is used for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin condi ions.일반 설명
Dextrorotatory clemastine, R,R-2[2[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1- methylpyrrolidine hydrogen furnarate (1:1) (Tavist), has two chiral centers, each of which has the (R) absolute configuration. A comparison of the activities of the enantiomers indicates that the asymmetric center close to the terminal side chain nitrogen is of lesser importance to antihistaminic activity.? This member of the ethanolamine series is characterized by a long duration of action, with an activity that reaches a maximum in 5 to 7 hours and persists for 10 to 12 hours. It is well absorbed when administered orally, and it is excreted primarily in the urine. The side effects are those usually encountered with this series of antihistamines. Clemastine is closely related to chlorphenoxamine, which is used for its central cholinergic-blocking activity. Therefore, it is not surprising that clemastine has significant antimuscarinic activity.
생물학적 활성
H 1 -receptor antagonist. Clinically-used antihistamine.Clemastine fumarate 준비 용품 및 원자재
원자재
준비 용품
Clemastine fumarate 공급 업체
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