히푸르산
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히푸르산 속성
- 녹는점
- 187-191 °C (lit.)
- 끓는 점
- 311.69°C (rough estimate)
- 밀도
- 1,371 g/cm3
- 굴절률
- 1.5600 (estimate)
- 저장 조건
- Store below +30°C.
- 용해도
- 3.26g/L
- 산도 계수 (pKa)
- 3.62(at 25℃)
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 거의 흰색
- 수소이온지수(pH)
- 2.5-3.5 (10g/l, H2O, 20℃)(slurry)
- 수용성
- 물에 용해됩니다.
- Merck
- 14,4716
- BRN
- 1073987
- 안정성
- 안정적인. 산화제와 호환되지 않습니다.
- InChIKey
- QIAFMBKCNZACKA-UHFFFAOYSA-N
- LogP
- 0.771
- CAS 데이터베이스
- 495-69-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-37/38-41-36/37/38 | ||
| 안전지침서 | 26-39-36/37-22 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | MR8150000 | ||
| F 고인화성물질 | 3-10 | ||
| TSCA | Yes | ||
| 위험 등급 | IRRITANT | ||
| HS 번호 | 29242990 | ||
| 기존화학 물질 | KE-02753 |
히푸르산 C화학적 특성, 용도, 생산
화학적 성질
White crystalline powder용도
N-Benzoylglycine also known as Hippuric Acid is the glycine conjugate of benzoic acid commonly found in ruminant urine. It is synthesized in the liver and its production is greatly increased following consuption of benzoic acid. In itself it does not have a direct biological function, however p-hydroxy-hippurica acid can be used as an inhibitor of Ca2+ ATPase.제조 방법
Preparation of Hippuric acid from Glycine.Principle: The hydroxy and amino functions can be easily benzoylated using Benzoyl chloride in aqueous alkaline conditions. This reaction is known as Schotten-Baumann reaction.
Reaction:
Procedure: Dissolve 0.5 g of glycine in 5 ml of 10% NaOH solution in a 25 ml conical flask. Add 0.9 ml of benzoyl chloride in five portions to the solution. Stopper the flask and shake vigorously after each addition until all the benzoyl chloride is reacted. Transfer the solution to a beaker and add few grams of ice and add conc. HCl slowly with stirring until the solution is acidic to litmus paper. Filter the crystalline precipitate of the product on a Buchner funnel, wash with cold water and drain well. Place the solid in a conical flask with 10 ml CCl4 and boil gently for 10 min. Allow the mixture to cool slightly, filter under gentle suction and wash with 10-20 ml CCl4. Record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product from boiling water (5 ml), with addition of decolorizing charcoal if necessary, filter the hot solution and cool the filtrate. The crystals of the product separate out. Filter, dry and record the melting point and TLC [using Butanal : acetic acid: water (4 : 1 : 1) as solvent or CHCl3:methanol (9 : 1) or toluene].
정의
ChEBI: An N-acylglycine in which the acyl group is specified as benzoyl.Purification Methods
Crystallise the acid from boiling H2O. Dry it over P2O5. Also purify it by dissolving 135-140g in 2L of boiling H2O, filtering through a steam-heated funnel and allowing to crystallise at ~20o (yield 115-122g first crop, m 186-187o). [Ingersoll & Babcock Org Synth Coll Vol II 328 1943, Beilstein 9 225, I 100.]히푸르산 준비 용품 및 원자재
원자재
준비 용품
히푸르산 공급 업체
글로벌( 493)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12470 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 16799 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15965 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
히푸르산 관련 검색:
벤젠술포닐클로라이드 히푸르산 N-프탈로일글리신 폴린 산, 칼슘 염 요산
N-BENZOYL-DL-ALANINE
4-NITROHIPPURIC ACID
Ethyl N-benzoyl-L-tyrosinate
P-NITROBENZOYL-L-GLUTAMIC ACID
Ethyl N-benzoyl-L-argininate hydrochloride
4-METHYLHIPPURIC ACID
N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID DIETHYL ESTER
(R)-(+)-1-(4-Methylphenyl)ethylamine
N-ALPHA-BENZOYL-L-ARGININE
Salicyluric acid
DIETHYL BENZAMIDOMALONATE
BZ-GLU-OH
4-Aminohippuric acid