Gliquidone
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Gliquidone 속성
- 녹는점
- 179 °C
- 밀도
- 1.34±0.1 g/cm3(Predicted)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- ≥22.4 mg/mL in DMSO; insoluble in H2O; ≥2.455 mg/mL in EtOH with gentle warming and ultrasonic
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 5.12±0.10(Predicted)
- 색상
- 흰색에서 거의 흰색
- Merck
- 14,4443
- CAS 데이터베이스
- 33342-05-1(CAS DataBase Reference)
안전
| 안전지침서 | 24/25 | ||
|---|---|---|---|
| RTECS 번호 | DB1584250 | ||
| HS 번호 | 29147000 | ||
| 기존화학 물질 | KE-09231 |
Gliquidone C화학적 특성, 용도, 생산
개요
Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 μM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 10 μM in a transactivation assay). Gliquidone (0.2 nmol/g) decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats. It decreases blood glucose levels, serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and hepatic lipid peroxidation and increases hepatic glutathione (GSH) levels in a rat model of diabetes induced by streptozotocin (STZ; ) when administered at a dose of 10 mg/kg.용도
Gliquidone is an anti diabetic agent used in the treatment of hypoglycemia which leads to an increased risk in diabetic cardiovascular disease. Also used in the treatment diabetic nephropathy.위험도
Low toxicity by ingestion. A reproductive hazard.Gliquidone 준비 용품 및 원자재
원자재
시클로헥실이소시아네이트
6-bromo-1,2,3,4-tetrahydro-4,4-dimethylquinoline hydrochloride
4,4'-설포닐다이페놀
Potassium T-Butylate
p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)ethyl]benzenesulphonamide
준비 용품
Gliquidone 공급 업체
글로벌( 261)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 |
admin@hbouhuang.com | China | 2642 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
| Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com |
jocelynpan@zjarts.com | CHINA | 993 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |