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L-트레오-디하이드로스핑고신

L-트레오-디하이드로스핑고신 구조식 이미지

카스 번호:: 15639-50-6

한글명:: L-트레오-디하이드로스핑고신

동의어(한글):: L-트레오-디하이드로스핑고신

상품명:: L-THREO-DIHYDROSPHINGOSINE

동의어(영문):: SAFINGOL;L-threo-dihydrospingosine;L-THREO-DIHYDROSPHINGOSINE;L-THREO-SPHINGANINE, C18 CHAIN;L-threo-dihydrosphingosine (d18:0);L-threo-Dihydrosphingosine (Safingol);Safingol - CAS 15639-50-6 - Calbiochem;1,3-Octadecanediol, 2-amino-, (2S,3S)-;L-THREO-DIHYDROSPHINGOSINE (D18:0);SAFINGOL

CBNumber:: CB1192274

분자식:: C18H39NO2

포뮬러 무게:: 301.51

MOL 파일:: 15639-50-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 67

L-트레오-디하이드로스핑고신 속성

녹는점: 126-128 °C

끓는 점: 446.2±25.0 °C(Predicted)

밀도: 0.927±0.06 g/cm3(Predicted)

인화점: 110 °C

저장 조건: -20°C

용해도: ≤0.25mg/ml in ethanol

물리적 상태: 흰색 고체

산도 계수 (pKa): 12.57±0.45(Predicted)

안전

WGK 독일	3

L-트레오-디하이드로스핑고신 C화학적 특성, 용도, 생산

용도

L-threo-Dihydrosphingosine is a lyso-sphingolipid protein kinase C inhibitor. It suppresses the growth of human oral squamous cell carcinoma (SCC) cells.

일반 설명

A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and ³H-phorbol dibutyrate binding of purified rat brain PKC (IC₅₀ = 37.5 μM and 31 μM, respectively). Inhibits human PKC_α, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC₅₀ = 40 μM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.

Biochem/physiol Actions

Sphingosine kinase inhibitor; protein kinase C alpha (PKCα) -specific inhibitor; Sphingosine analog; potentiates the effect of doxorubicin (DOX) in tumor-bearing animals.

L-트레오-디하이드로스핑고신 준비 용품 및 원자재

원자재

준비 용품

L-트레오-디하이드로스핑고신 공급 업체

글로벌( 67)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30250	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52861	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50003	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
Yichang Zhongyitai Trading Co., Ltd.	0717-6449896 13886658719	root@zhongyitai.com	China	1977	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Alfa Chemistry	1-516-6625404	support@alfa-chemistry.com	United States	9171	60
Codow Chemical Co.,Ltd.	18620099427	amy@howeipharm.com	China	17698	55

L-트레오-디하이드로스핑고신 관련 검색:

D-THREO-DIHYDROSPHINGOSINE DL-THREO-DIHYDROSPHINGOSINE N-DODECANOYL-NBD-L-THREO-DIHYDROSPHINGOSINE,N-C12-NBD-L-THREO-DIHYDROSPHINGOSINE, FLUORESCENT C6 NBD-L-THREO-DIHYDROSPHINGOSINE DIHYDROSPHINGOSINE, L-THREO [4,5-3H] C12 NBD-L-THREO-DIHYDROSPHINGOSINE N-C6-NBD-L-THREO-DIHYDROSPHINGOSINE, FLUORESCENT,N-HEXANOYL-NBD-L-THREO-DIHYDROSPHINGOSINE Cedefingol L-THREO-DIHYDROSPHINGOSINE