ChemicalBook >제품 카탈로그 >제약 중간체>벌크 의약품 중간체>N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 구조식 이미지

카스 번호:: 444731-74-2

상품명:: N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine

동의어(영문):: BNKY007-PZ01;Pazopanib Impurity 20;2H-indazol-6aMine,2,3-diMethyl.HCl(1:1);N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-;6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole;N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine;N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine ISO 9001：2015 REACH

CBNumber:: CB12526161

분자식:: C13H12ClN5

포뮬러 무게:: 273.72

MOL 파일:: 444731-74-2.mol

속성

안전

용도

공급 업체 134

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 속성

녹는점: >216oC (dec.)

끓는 점: 550.0±35.0 °C(Predicted)

밀도: 1.41±0.1 g/cm3(Predicted)

저장 조건: Hygroscopic, Refrigerator, under inert atmosphere

용해도: 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 2.56±0.30(Predicted)

색상: 옅은 오렌지색에서 밝은 갈색까지

안정성: 흡습성

안전

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine C화학적 특성, 용도, 생산

용도

N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine (N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine) is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

주요 응용

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine is a valuable organic compound that could be used to synthesize N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, N- (2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, and others.

Synthesis

2,3-dimethyl-6-amino-2H- indazole 5.00g,2,4-Dichloropyrimidine 13.9g and sodium bicarbonate 10.4g were dissolved in 100mL absolute ethanol and heated to 79°C.After refluxing for 4 h, cool to room temperature and filter. The cake was washed well with ethyl acetate, and the filtrate was collected. Concentrate under reduced pressure, remove the solvent, and fully beat with ethyl acetate and filter to give an off-white solid. Recrystallization from methanol gave 7.64 g of product N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine as a white solid, yield: 90.0%.

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 준비 용품 및 원자재

원자재

2,3-DIMETHYL-2H-INDAZOL-6-AMINE 2,3-dimethyl-2H-indazol-6-amine hydrochloride 2,4-Dichloropyrimidine

준비 용품

N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 공급 업체

글로벌( 134)공급 업체

공급자	전화	이메일	국가	제품 수	이점
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Yangzhou Qinyuan Pharmatech Co.,ltd	+86-18752526868	jennysun@yzqyyykj.com	China	64	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15957	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	341	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine 관련 검색:

Pazopanib Related Compound 3 (6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid Pazopanib Impurity 9 N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE Pazopanib Pazopanib-d6 2,3-dimethyl-2H-indazol-6-amine hydrochloride Pazopanib Related Compound 2 1,3-Dimethyl-6-nitro-1H-indazole 2-Methyl-5-nitrobenzenesulfonamide 3-AMINO-4-METHYLBENZENESULFONAMIDE 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) 1,3-DiMethyl-6-aMino-1H-indazole 4(1H)-Pyrimidinone, 2-chloro- (9CI) Pazopanib Impurity 10