눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid C화학적 특성, 용도, 생산
화학적 성질
Off-White Solid
용도
Intermediate in the preparation of MEK inhibitors.
Synthesis
To a solution of methyl-3,4-diflluoro-2-((2-flluoro-4-iodophenyl)amino)benzoate (23, 6.0 g, 23.8 mmol) in methanol (80 mL) and water (80 mL) was added LiOH (7.8 g, 195 mmol). The reaction mixture was stirred at 78 C in an oil bath for 1 h. After cooling, the reaction mixture was acidified to pH = 2 with a 2 N HCl solution. The solid was filtered and washed with water to provide 2-(2-Fluoro-4-iodoanilino)-3,4-difluoro benzoic Acid (5.11 g, 96%) as a white solid.
2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid 준비 용품 및 원자재