Emamectin B1 Benzoate;eprinex;Eprinomectin (Mixture of B1a and B1b);MK 397;EPRINOMECTIN;Eprinomection;EprinomectinB1;Acetaminobamectin;Acetaminoabamectin;acetamido abamectin
Eprinomectin is a semisynthetic avermectin that consists
of a mixture of two homologues, eprinomectin
B1a (4 epi-acetylamino-4 -deoxy-avermectin B1; 90%) and
eprinomectin B1b (10%).Eprinomectin was developed
as a topical endectocide for all categories of cattle
including lactating dairy cattle, and the process by
which eprinomectin was selected for further development
has been described (90). Briefly, several hundred avermectin/
milbemycin analogues were screened in a sheep
model for efficacy against a range of endoparasites and
in lactating dairy cows for a low milk:plasma partitioning
ratio. Themilk:plasma ratio for eprinomectin is <0.2; ivermectin,
by comparison, partitions equally between milk
and plasma.
화학적 성질
Crystalline Solid
용도
Eprinomectin is a mixture of eprinomectins B1a and B1b in a 9:1 ratio, produced from a mixture of avermectin B1a and B1b. Eprinomectin is used commercially as a topical endectocide (insecticide, miticide and nematocide) for cattle, including lactating dairy cows. Like all avermectins and milbemycins, eprinomectin acts by binding to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite, mite or insect.
