우라실 겨자 C화학적 특성, 용도, 생산
개요
Uracil mustard appears as creamy/off-white, odourless, crystalline powder. It is used as an
anti-cancer medicine. Uracil mustard is a chemotherapy drug that belongs to the class of
alkylating agents. It is used for its anti-neoplastic properties. It works by damaging deoxyribonucleic
acid (DNA), primarily in cancer cells that preferentially take up the uracil due
to their need to make nucleic acids during their rapid cycles of cell division. At high concentrations
of the drug, cellular RNA and protein synthesis are also suppressed. The DNA
damage leads to apoptosis of the affected cells. Chemically it is a derivative of nitrogen
mustard and uracil. Uracil mustard is a non-combustible substance itself; it does not burn
but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidisers
and may ignite combustibles – wood, paper, oil, clothing, etc. Contact with metals
may evolve flammable hydrogen gas. Containers may explode when heated.
용도
Antineoplastic.
일반 설명
Creamy white crystals or off-white powder. Used as an anti-cancer medicine.
공기와 물의 반응
Slightly soluble in water [Merck].
반응 프로필
URACIL MUSTARD (500 MG) (FOR U.S. SALE ONLY) reacts as a base.
건강위험
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
화재위험
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Safety Profile
Suspected carcinogen withexperimental carcinogenic and neoplastigenic data. Adeadly poison by ingestion and intraperitoneal routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of Cl?? and NOx.
Carcinogenicity
Uracil mustard was reportedly
carcinogenic in both mice and rats following multiple intraperitoneal
injections. It produced a dose-related increase in
lung tumor incidence in mice and tumors in a variety of other
organs in both mice and rats. The IARC reviewed the
preceding data and deemed it “sufficient evidence of carcinogenicity
in animals.” Based on this information, its mutagenic
potential, analogy to other nitrogen mustards, and a
lack of carcinogenicity data in humans, the IARC classified
uracil mustard in Group 2B (possibly carcinogenic to
humans). Uracil mustard compared to nitrogen mustard
itself in the same assay (lung tumor assay in strain A mice,
intraperitoneal dosing) was found to be more potent as a
tumorigen than nitrogen mustard. An in vitro assay to
predict carcinogenicity gave a positive response predicting
that uracil mustard would be a carcinogen in rodent test
models. The assay used focus formation in a stable bovine
papillomavirus type 1 DNA carrying a mouse fibroblast cell
line that does not require transfection, infection with virus,isolation of primary cells from animals, or addition of a
microsomal fraction.
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