POLYPHYLLIN D

POLYPHYLLIN D 구조식 이미지
카스 번호:
50773-41-6
상품명:
POLYPHYLLIN D
동의어(영문):
Paris I;Saponin Pa;Polyphyllin;Polyphyllin C;Polyphyllin I;POLYPHYLLIN D;Polyphyllin A;Polyphillin D;Polyphyllin Ⅰ;GLYCO-DIOSGENIN
CBNumber:
CB3511798
분자식:
C44H70O16
포뮬러 무게:
855.02
MOL 파일:
50773-41-6.mol

POLYPHYLLIN D 속성

녹는점
>245°C (dec.)
밀도
1.40
저장 조건
Hygroscopic, -20°C Freezer, Under inert atmosphere
용해도
DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열), 피리딘(약간 용해됨)
산도 계수 (pKa)
12?+-.0.70(Predicted)
물리적 상태
고체
물리적 상태
단단한 모양
색상
하얀색

안전

HS 번호 29389090

POLYPHYLLIN D C화학적 특성, 용도, 생산

개요

Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity. It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells. Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.

용도

Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers.

POLYPHYLLIN D 준비 용품 및 원자재

원자재

준비 용품


POLYPHYLLIN D 공급 업체

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Shaanxi Haibo Biotechnology Co., Ltd
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Shanghai Standard Technology Co., Ltd.
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