(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one 구조식 이미지
카스 번호:
139893-81-5
상품명:
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
동의어(영문):
(1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one;Edoxaban Impurity 80;6-Oxabicyclo[3.2.1]octan-7-one, 4-bromo-, (1S-exo)- (9CI);(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-oneQ: What is
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one Q: What is the CAS Number of
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one C화학적 특성, 용도, 생산
용도
Used as Edoxaban impurity.
Synthesis
(1S)-Cyclohex-3-ene-1-carboxylic acid (II) (5 g) was dissolved in dichloromethane (25 mL). To this solution, N-bromosuccinimide (1.1 mole) was added at room temperature. In two lots, calcium oxide (0.25 mole) was charged to the Suspension. The reaction mixture was stirred at 20 to 25°C for 1 hour and filtered. The bed was washed with dichloromethane (10 mL). The washings were combined with the filtrate, and the solvent was recovered under vacuum at 35 to 40 °C. Deionized water (50 mL) was charged to the solid, heated to 50 °C, stirred for 10 minutes, and filtered. The bed was washed with deionized water (10 mL) and suction dried. The solid was dried under vacuum at 45-50 °C to get (1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one. Yield: 61%
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one 준비 용품 및 원자재
